7-amino-6-[4-(2,3-dichloro-benzenesulfonylamino)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester | 952202-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-amino-6-[4-(2,3-dichloro-benzenesulfonylamino)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
• 英文别名: ethyl 7-amino-6-[4-[(2,3-dichlorophenyl)sulfonylamino]phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylate
• CAS: 952202-47-0
• 化学式: C₂₁H₁₇Cl₂N₅O₄S
• 分子量: 506.369
• InChiKey: ZUDGHQKMBNFRKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  7-amino-6-[4-(2,3-dichloro-benzenesulfonylamino)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester 在 sodium hydroxide 、 N-羟基-7-氮杂苯并三氮唑 、 乙醇 、 水 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 N-{4-[7-amino-3-(3-dimethylamino-pyrrolidine-1-carbonyl)-pyrazolo[1,5-a]pyrimidin-6-yl]-phenyl}-2,3-dichloro-benzenesulfonamide
  参考文献：
  名称：

  WO2007/113000

  摘要：

  公开号：
• 作为产物：
  描述：

  7-amino-6-(4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester 在 5%-palladium/activated carbon 吡啶 、 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 20.0 ℃ 、100.0 kPa 条件下， 反应 29.0h， 生成 7-amino-6-[4-(2,3-dichloro-benzenesulfonylamino)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  WO2007/113000

  摘要：

  公开号：

文献信息

• 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors
  申请人：Masuya Keiichi

  公开号：US20090275593A1

  公开（公告）日：2009-11-05

  The invention relates to 3-substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidine compounds, their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase, especially tie-2 kinase, activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds.

  本发明涉及3-取代N-(芳基或杂环芳基)-吡唑并[1,5-a]嘧啶化合物，它们作为激酶抑制剂的用途，包括所述化合物的新药物制剂，所述化合物用于温血动物，特别是人类的诊断或治疗治疗，它们用于治疗疾病或制造对于对激酶调节有响应的疾病的药物制剂，特别是Tie-2激酶活性，治疗方法包括向温血动物，特别是人类，给予所述化合物的给药，以及制造所述化合物的过程。
• 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-a]PYRIMIDINES AS KINASE INHIBITORS
  申请人：NOVARTIS AG

  公开号：EP2004653A1

  公开（公告）日：2008-12-24
• 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-A]PYRIMIDINES AS KINASE INHIBITORS
  申请人：Novartis AG

  公开号：EP2004653B1

  公开（公告）日：2009-12-30
• METHOD AND COMPOSITIONS FOR INHIBITION OF NAPHTHENIC ACID INDUCED CORROSION
  申请人：BAKER HUGHES INCORPORATED

  公开号：EP2046918A1

  公开（公告）日：2009-04-15
• Method and compositions for inhibition of naphthenic acid induced corrosion
  申请人：Zetlmeisl Michael J.

  公开号：US20080001125A1

  公开（公告）日：2008-01-03

  Corrosion induced by the presence of naphthenic acids in hydrocarbon fluids, particularly where such fluids are at elevated temperatures, may be inhibited or controlled through use of corrosion inhibiting compositions comprising a combination of a minor portion of a phosphorus-based constituent and a major portion of a sulfur-based constituent, nitrogen-based constituent, or combination thereof. In another embodiment the sulfur-based constituent and/or nitrogen-based constituent may be used without any phosphorus-based constituent. Where the compounds are appropriately selected, the compositions may inhibit corrosion to a degree comparable or nearly comparable to the inhibition provided by an equal amount of some conventional phosphorus-based compounds alone, but are significantly less likely to impair catalyst activity in downstream cracking and refinery operations.