3>angiotensin III | 95936-83-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3>angiotensin III
• 英文别名: H-Arg-Val-Tyr(Me)-Ile-His-Pro-Phe-OH；(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
• CAS: 95936-83-7
• 化学式: C₄₇H₆₈N₁₂O₉
• 分子量: 945.132
• InChiKey: ASBAXIPCAMPRMD-PJKCPVONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  68
• 可旋转键数：
  26
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  331
• 氢给体数：
  10
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  BOC-L-脯氨酸 、 BOC-L-异亮氨酸 、 BOC-L-苯丙氨酸 、 N-叔丁氧羰基-N(咪唑)-(4-甲基苯磺酰基)-L-组氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3>angiotensin III
  参考文献：
  名称：

  含有O-甲基酪氨酸和D-色氨酸的血管紧张素II和III的类似物的合成和生物学活性。

  摘要：

  通过固相方法合成了取代酪氨酸和/或苯丙氨酸残基的血管紧张素II和III（ANG II和ANG III）的类似物，并通过（羧甲基）纤维素色谱和反相HPLC进行了纯化。在大鼠分离子宫试验中确定了这些肽的拮抗剂和激动剂效力。[Sar1，Tyr（Me）4] ANG II，[Tyr（Me）3] ANG III，[Sar1，D-Trp4] ANG II，[D-Trp3] ANG III，[Sar1，D-Trp8] ANG II， [D-Trp7] ANG III，[Sar1，Tyr（Me）4，Ile8] ANG II，[Tyr（Me）3，Ile7] ANG III，[Sar1，D-Trp4，Ile8] ANG II，[D-Trp3 ，Ile7] ANG III，[Sar1，Tyr（Me）4，D-Trp8] ANG II和[Tyr（Me）3，D-Trp7] ANG III的拮抗活性（pA2）分别为8.1，小于6。小于6，小于6，（7

  DOI：

  10.1021/jm00383a015

文献信息

• Synthesis and biological activities of analogs of angiotensins II and III containing O-methyltyrosine and D-tryptophan
  作者：John M. Matsoukas、Mahesh H. Goghari、Martin N. Scanlon、Kevin J. Franklin、Graham J. Moore

  DOI：10.1021/jm00383a015

  日期：1985.6

  substitution. Substitution of the Tyr residue in ANG II, but not ANG III, provides a new route for the synthesis of potent and competitive angiotensin antagonists. Differences in the biological properties of ANG II and ANG III analogues substituted at the Tyr residue suggest different binding/conformation requirements for the two endogenous ligands at angiotensin receptors in smooth muscle.

  通过固相方法合成了取代酪氨酸和/或苯丙氨酸残基的血管紧张素II和III（ANG II和ANG III）的类似物，并通过（羧甲基）纤维素色谱和反相HPLC进行了纯化。在大鼠分离子宫试验中确定了这些肽的拮抗剂和激动剂效力。[Sar1，Tyr（Me）4] ANG II，[Tyr（Me）3] ANG III，[Sar1，D-Trp4] ANG II，[D-Trp3] ANG III，[Sar1，D-Trp8] ANG II， [D-Trp7] ANG III，[Sar1，Tyr（Me）4，Ile8] ANG II，[Tyr（Me）3，Ile7] ANG III，[Sar1，D-Trp4，Ile8] ANG II，[D-Trp3 ，Ile7] ANG III，[Sar1，Tyr（Me）4，D-Trp8] ANG II和[Tyr（Me）3，D-Trp7] ANG III的拮抗活性（pA2）分别为8.1，小于6。小于6，小于6，（7