N-(3-(2-methyl-1H-indol-3-yl)propyl)acetamide | 1353013-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(3-(2-methyl-1H-indol-3-yl)propyl)acetamide
• 英文别名: N-[3-(2-methyl-1H-indol-3-yl)propyl]acetamide
• CAS: 1353013-82-7
• 化学式: C₁₄H₁₈N₂O
• 分子量: 230.31
• InChiKey: FEFDTORRBSMACU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-methyl-2,3,4,5-tetrahydro-pyridine 在 4-二甲氨基吡啶 、 水 、 对甲苯磺酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 42.25h， 生成 N-(3-(2-methyl-1H-indol-3-yl)propyl)acetamide
  参考文献：
  名称：

  A one-pot three-component reaction for the preparation of highly functionalized tryptamines

  摘要：

  We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2011.11.032

文献信息

• A one-pot three-component reaction for the preparation of highly functionalized tryptamines
  作者：Se Jeong Yeo、Yongxiang Liu、Xiang Wang

  DOI：10.1016/j.tet.2011.11.032

  日期：2012.1

  We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described. Published by Elsevier Ltd.