Pyrano[2,3-c]pyrazol-6(1H)-one, 3-methyl-1-phenyl-4-propyl- | 219766-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Pyrano[2,3-c]pyrazol-6(1H)-one, 3-methyl-1-phenyl-4-propyl-
• 英文别名: 3-methyl-1-phenyl-4-propylpyrano[2,3-c]pyrazol-6-one
• CAS: 219766-70-8
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: XKQMZASZPONXJR-UHFFFAOYSA-N

物化性质

• 熔点：
  80 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• 沸点：
  446.3±33.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-甲基-2-苯基-1,2-二氢吡唑-3-酮 、 丁酰乙酸乙酯 反应 0.06h， 以92%的产率得到Pyrano[2,3-c]pyrazol-6(1H)-one, 3-methyl-1-phenyl-4-propyl-
  参考文献：
  名称：

  Facile Synthesis of Pyrano[2,3‐c]pyrazol‐6‐one Derivatives Under Microwave Irradiation in Solvent‐Free Conditions

  摘要：

  A series of substituted 1H,6H-pyrano[2,3-c]pyrazol-6-one derivatives were synthesized from one-pot cyclocondensation of hydrazine derivatives or 1H-pyrazol-5-one derivatives with various ss-keto esters under solvent-free conditions using microwave irradiation in short time with good to excellent yields.

  DOI：

  10.1080/00397910500328886

文献信息

• Facile Synthesis of Pyrano[2,3‐c]pyrazol‐6‐one Derivatives Under Microwave Irradiation in Solvent‐Free Conditions
  作者：Mohammad M. Mojtahedi、Mohammad R. Jalali、Mohammad Bolourtchian

  DOI：10.1080/00397910500328886

  日期：2006.2

  A series of substituted 1H,6H-pyrano[2,3-c]pyrazol-6-one derivatives were synthesized from one-pot cyclocondensation of hydrazine derivatives or 1H-pyrazol-5-one derivatives with various ss-keto esters under solvent-free conditions using microwave irradiation in short time with good to excellent yields.