3,9,10,11-四甲氧基-5H-二苯并[a,c]环庚烯 | 127825-89-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 3,9,10,11-四甲氧基-5H-二苯并[a,c]环庚烯
• 中文别名: 甲基(6aR,7S,10aR)-6a,7,10a,12-四羟基-3,8-二甲氧基-1-甲基-6,10,11-三羰基-6,6a,7,10,10a,11-六氢四省-2-羧酸酯
• 英文名称: 3,9,10,11-tetramethoxy-5H-dibenzo[a,c]cycloheptene
• 英文别名: 3,9,10,11-Tetramethoxy-5H-dibenzo[a,c]cyclohepten；Dibenzo[c,E]cycloheptene, 2,3,4,7-tetramethoxy-；3,4,5,13-tetramethoxytricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,8,12,14-heptaene
• CAS: 127825-89-2
• 化学式: C₁₉H₂₀O₄
• 分子量: 312.365
• InChiKey: ZNKGVTKZFPQFCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,9,10,11-四甲氧基-5H-二苯并[a,c]环庚烯 在 钯 、 溶剂黄146 作用下， 生成 deaminocolchinol methyl ether
  参考文献：
  名称：

  Oxidation of Gas Mixtures Containing Dimethyl Sulfide, Hydrogen Sulfide, and Methanethiol Using a Two-Stage Biotrickling Filter

  摘要：

  A biofiltration technique was developed for removing a mixture of hydrogen sulfide (H2S), methanethiol (MeSH), and dimethyl sulfide (Me2S) from waste gases. Since H2S, especially at high concentrations, disturbs the removal of Me2S, two biotrickling filters with different microbes and operating pH levels were connected in series to create a two-stage system. Different loads of these gases were studied in order to determine their impact on the removal capacity of the system. The microbial consortia for these filters were enriched from the sludge of a Finnish refinery with bubbling H2S or Me2S. Acclimation for Me2S took 2 weeks, though no acclimation time was needed for the other gases. The first filter, at a pH of 2, removed most of the H2S and some of the MeSH and Me2S. The second filter, at a pH of similar to6.5, removed the rest of the MeSH and most of the Me2S. The total maximum loads of the whole two-stage biotrickling filter were 1150 g/m(3)/day for H2S-S (suffix S indicates the results are counted as sulfur amounts), 879 g/m(3)/day for Me2S-S, and 66 g/m(3)/day for MeSH-S treated in a gas mixture. The average removal efficiencies for all gases tested were 99% or higher.

  DOI：

  10.1080/10473289.2001.10464260
• 作为产物：
  描述：

  ethyl 2',3',4,4'-tetramethoxy-1,1'-biphenyl-2-propionate 在 sodium hydroxide 、 sodium tetrahydroborate 、 三氟乙酸酐 作用下， 以 甲醇 、 三氟乙酸 为溶剂， 反应 15.0h， 生成 3,9,10,11-四甲氧基-5H-二苯并[a,c]环庚烯
  参考文献：
  名称：

  脱氨基乙炔基甲基醚：由2,3,4,4'-四甲氧基联苯-2-甲醛催化合成。脱氨基联苯甲酰基甲基醚和脱氢类似物的抗微管蛋白作用比较

  摘要：

  由四甲氧基取代的联苯-2-碳-醛12经由三环酮20和5，6-二氢同系物11合成了脱氨基联苯甲酰基甲基醚9。化合物9在各个方面与经由秋水仙碱经6,7-二氢同系物10制备的材料相同。测量微管蛋白聚合的抑制在体外表现出的化合物4，5，和9 - 11秋水仙碱的alloseries的是特别有效的抑制剂。

  DOI：

  10.1002/hlca.19890720805

文献信息

• Cook et al., Journal of the Chemical Society, 1944, p. 322,324
  作者：Cook et al.

  DOI：——

  日期：——
• Cook et al., Journal of the Chemical Society, 1952, p. 607,610
  作者：Cook et al.

  DOI：——

  日期：——
• Oxidation of Gas Mixtures Containing Dimethyl Sulfide, Hydrogen Sulfide, and Methanethiol Using a Two-Stage Biotrickling Filter
  作者：Arja Ruokojärvi、Juhani Ruuskanen、Pertti J. Martikainen、Minna Olkkonen

  DOI：10.1080/10473289.2001.10464260

  日期：2001.1

  A biofiltration technique was developed for removing a mixture of hydrogen sulfide (H2S), methanethiol (MeSH), and dimethyl sulfide (Me2S) from waste gases. Since H2S, especially at high concentrations, disturbs the removal of Me2S, two biotrickling filters with different microbes and operating pH levels were connected in series to create a two-stage system. Different loads of these gases were studied in order to determine their impact on the removal capacity of the system. The microbial consortia for these filters were enriched from the sludge of a Finnish refinery with bubbling H2S or Me2S. Acclimation for Me2S took 2 weeks, though no acclimation time was needed for the other gases. The first filter, at a pH of 2, removed most of the H2S and some of the MeSH and Me2S. The second filter, at a pH of similar to6.5, removed the rest of the MeSH and most of the Me2S. The total maximum loads of the whole two-stage biotrickling filter were 1150 g/m(3)/day for H2S-S (suffix S indicates the results are counted as sulfur amounts), 879 g/m(3)/day for Me2S-S, and 66 g/m(3)/day for MeSH-S treated in a gas mixture. The average removal efficiencies for all gases tested were 99% or higher.
• Deaminocolchinyl Methyl Ether: Synthesis from 2,3,4,4′-Tetramethoxybiphenyl-2-carbaldehyde. Comparison of antitubulin effects of deaminocolchinyl methyl ether and dehydro analogs
  作者：Olivier Boyé、Yoshikuni Itoh、Arnold Brossi

  DOI：10.1002/hlca.19890720805

  日期：1989.12.13

  Synthesis of deaminocolchinyl methyl ether 9 was achieved from tetramethoxy-substituted biphenyl-2-carb-aldehyde 12via tricyclic ketone 20 and 5,6-didehydro congener 11. Compound 9 was identical in every respect with material prepared from colchicine via 6,7-didehydro congener 10. Measuring inhibition of tubulin polymerization in vitro showed compounds 4, 5, and 9–11 of the alloseries of colchicinoids

  由四甲氧基取代的联苯-2-碳-醛12经由三环酮20和5，6-二氢同系物11合成了脱氨基联苯甲酰基甲基醚9。化合物9在各个方面与经由秋水仙碱经6,7-二氢同系物10制备的材料相同。测量微管蛋白聚合的抑制在体外表现出的化合物4，5，和9 - 11秋水仙碱的alloseries的是特别有效的抑制剂。