3,9-二氯-7H-苯并[de]蒽-7-酮 | 66104-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 3,9-二氯-7H-苯并[de]蒽-7-酮
• 英文名称: 3,9-dichloro-benz[de]anthracen-7-one
• 英文别名: 3,9-Dichlor-benz[de]anthracen-7-on；6.Bz 1-Dichlor-benzanthron；3,9-dichloro-7H-benz(de)anthracen-7-one；7H-Benz[de]anthracen-7-one, 3,9-dichloro-；3,9-dichlorobenzo[b]phenalen-7-one
• CAS: 66104-58-3
• 化学式: C₁₇H₈Cl₂O
• 分子量: 299.156
• InChiKey: CWOMZMMYXCMUCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,9-二氯-7H-苯并[de]蒽-7-酮 在 chromium(VI) oxide 、 硫酸 、 溶剂黄146 作用下， 生成 6-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid methyl ester
  参考文献：
  名称：

  Intracranial subdural hematoma after unintended durotomy during spine surgery

  摘要：

  Purpose: To report a case of intracranial subdural hematoma occurring after a spinal ducal tear that was made unintentionally during the course of a posterior laminectomy and spinal fusion at the L-5-S-1 level. The possible physiopathological mechanisms are discussed.Clinical features: On the fourth postoperative day, a 59-yr-old woman displayed persistent headache following unintended durotomy during spine implant revision. Perioperative blood loss was 2840 mL and intravascular replacement was about 3000 mL. She was hydrated with iv fluids and treated with non-steroidal anti-inflammatory drugs. The symptoms improved but persisted. With the aggravation of the headache complicated with unconsciousness and the appearance of focal neurological signs on the eighth day, a computed tomography was obtained and revealed a right subdural hematoma. Following surgical drainage, the patient made an uneventful recovery.Conclusion: This case reminds us that subdural hematoma formation can complicate durotomy during spine surgery. Neurological deterioration in the postoperative period should prompt clinicians to rule out the diagnosis and intervene rapidly as appropriate.

  DOI：

  10.1007/bf03020428
• 作为产物：
  描述：

  3-chloro-9-nitro-benz[de]anthracen-7-one 在 三氯苯 作用下， 生成 3,9-二氯-7H-苯并[de]蒽-7-酮
  参考文献：
  名称：

  DE490989

  摘要：

  公开号：

文献信息

• Examen de la preuve dans la documentation sur l’anesthésie: enquête et évaluation des articles sur les céphalées obstétricales post-ponction durale
  作者：Peter T. -L. Choi、Saramin E. Galinski、Stefan Lucas、Lawrence Takeuchi、Alejandro R. Jadad

  DOI：10.1007/bf03020418

  日期：2002.1

  Purpose: To describe a bibliographic database on the literature of postdural puncture headache (PDPH) in the obstetrical population, to describe the research architecture in this field, and to evaluate the quality of case-control studies, cohort studies, and controlled clinical trials on PDPH.Methods: Computerized bibliographic searches, citation review, and hand searches were conducted to find all relevant citations on incidence, clinical course, prevention, or treatment of PDPH in parturients. The study design and topic(s) covered by each study were evaluated. Case-control studies and cohort studies were evaluated using the Quality Index; clinical trials were evaluated using the Jadad scale.Results: One hundred ninety-six relevant citations were published between 1949 and 1999. Research on PDPH has been increasing rapidly with the majority of studies published in the 1990's. Incidence and prevention were the focus of over half of all citations. Optimal study designs were infrequently utilized. The methodological quality was poor for observational studies (Quality Index 10/29) and clinical trials (Jadad scale 2/5).Conclusion: Although the amount of research on PDPH in parturients is increasing, use of optimal study designs and improvement in methodology is needed.
• 115. The constitution of the chlorination products of benzanthrone
  作者：R. S. Cahn、W. O. Jones、J. L. Simonsen

  DOI：10.1039/jr9330000444

  日期：——
• DE436888
  申请人：——

  公开号：——

  公开（公告）日：——
• Lauer; Hirata, Journal fur praktische Chemie (Leipzig 1954), 1936, vol. <2> 145, p. 287,289
  作者：Lauer、Hirata

  DOI：——

  日期：——
• DE436533
  申请人：——

  公开号：——

  公开（公告）日：——