N-(2-chloropyridin-3-yl)-2-(1H-indol-3-yl)acetamide | 503617-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(2-chloropyridin-3-yl)-2-(1H-indol-3-yl)acetamide
• CAS: 503617-73-0
• 化学式: C₁₅H₁₂ClN₃O
• 分子量: 285.733
• InChiKey: DLUMOLUEGWOCMD-UHFFFAOYSA-N

物化性质

• 沸点：
  579.6±50.0 °C(Predicted)
• 密度：
  1.422±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 N-(2-chloropyridin-3-yl)-2-(1H-indol-3-yl)acetamide 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以45%的产率得到2-(1-Benzyl-1H-indol-3-yl)-N-(2-chloro-pyridin-3-yl)-acetamide
  参考文献：
  名称：

  Synthesis and Antioxidant Properties of Novel N-Substituted Indole-2-carboxamide and Indole-3-acetamide Derivatives

  摘要：

  A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5,10,15,17 are very efficient antioxidants compared to (X-tocopherol.

  DOI：

  10.1002/1521-4184(200209)335:7<331::aid-ardp331>3.0.co;2-7
• 作为产物：
  描述：

  3-氨基-2-氯吡啶 、 3-吲哚乙酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以43%的产率得到N-(2-chloropyridin-3-yl)-2-(1H-indol-3-yl)acetamide
  参考文献：
  名称：

  Synthesis and Antioxidant Properties of Novel N-Substituted Indole-2-carboxamide and Indole-3-acetamide Derivatives

  摘要：

  A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5,10,15,17 are very efficient antioxidants compared to (X-tocopherol.

  DOI：

  10.1002/1521-4184(200209)335:7<331::aid-ardp331>3.0.co;2-7

文献信息

• Synthesis and Antioxidant Properties of Novel N-Substituted Indole-2-carboxamide and Indole-3-acetamide Derivatives
  作者：Süreyya Ölgen、Tülay Çoban

  DOI：10.1002/1521-4184(200209)335:7<331::aid-ardp331>3.0.co;2-7

  日期：2002.9

  A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5,10,15,17 are very efficient antioxidants compared to (X-tocopherol.