3,6-bis(2,4,6-triisopropylbenzenesulfonyl)-3,6-diazabicyclo[3.1.0]hexane | 873087-94-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,6-bis(2,4,6-triisopropylbenzenesulfonyl)-3,6-diazabicyclo[3.1.0]hexane
• 英文别名: 3,6-Bis[[2,4,6-tri(propan-2-yl)phenyl]sulfonyl]-3,6-diazabicyclo[3.1.0]hexane；3,6-bis[[2,4,6-tri(propan-2-yl)phenyl]sulfonyl]-3,6-diazabicyclo[3.1.0]hexane
• CAS: 873087-94-6
• 化学式: C₃₄H₅₂N₂O₄S₂
• 分子量: 616.93
• InChiKey: AIOMEWALKUYJSP-UHFFFAOYSA-N

物化性质

• 熔点：
  180-182 °C
• 沸点：
  655.8±65.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  91.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,6-bis(2,4,6-triisopropylbenzenesulfonyl)-3,6-diazabicyclo[3.1.0]hexane 在 五甲基二乙烯三胺 、 仲丁基锂 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 4.0h， 以81%的产率得到2,4,6-tri(propan-2-yl)-N-[2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]but-3-ynyl]benzenesulfonamide
  参考文献：
  名称：

  Organolithium-mediated conversion of β-functionalised aziridines into alkynyl amino alcohols and diamines

  摘要：

  二氢呋喃和二氢吡咯N-三异丙基苯磺酰氮丙啶分别直接转化为炔基氨基醇和二胺，可使用3当量的叔丁基锂-PMDETA在THF中实现；使用正丁基锂和（∘）-sparteine在Et2O中可得到60%ee的炔基氨基醇。

  DOI：

  10.1039/b510920e
• 作为产物：
  描述：

  2,4,6-三异丙基苯磺胺 在 吡啶 、 苄基三乙基氯化铵 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 乙腈 为溶剂， 反应 128.0h， 生成 3,6-bis(2,4,6-triisopropylbenzenesulfonyl)-3,6-diazabicyclo[3.1.0]hexane
  参考文献：
  名称：

  The output of amplified spontaneous emission lasers

  摘要：

  The output of amplified spontaneous emission (ASE) lasers such as X-ray lasers operated without mirrors is calculated exactly for Gaussian and Lorentzian small signal gain profiles by a simple Taylor series expansion. The accuracy of the 'Linford' formula commonly used as an approximation for the output of ASE lasers is evaluated by comparison to our exact solutions. The Linford formula is accurate to better than 10% for intensities produced by a Gaussian gain profile, but requires multiplication by a correction factor of at gain length product greater than 5 for Lorentzian gain profiles. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.jqsrt.2006.02.064

文献信息

• The output of amplified spontaneous emission lasers
  作者：H. Huang、G.J. Tallents

  DOI：10.1016/j.jqsrt.2006.02.064

  日期：2006.12

  The output of amplified spontaneous emission (ASE) lasers such as X-ray lasers operated without mirrors is calculated exactly for Gaussian and Lorentzian small signal gain profiles by a simple Taylor series expansion. The accuracy of the 'Linford' formula commonly used as an approximation for the output of ASE lasers is evaluated by comparison to our exact solutions. The Linford formula is accurate to better than 10% for intensities produced by a Gaussian gain profile, but requires multiplication by a correction factor of at gain length product greater than 5 for Lorentzian gain profiles. (c) 2006 Elsevier Ltd. All rights reserved.
• Organolithium-mediated conversion of β-functionalised aziridines into alkynyl amino alcohols and diamines
  作者：Jianhui Huang、Peter O'Brien

  DOI：10.1039/b510920e

  日期：——

  The direct conversion of dihydrofuran and dihydropyrrole N-triisopropylbenzenesulfonyl aziridines into alkynyl amino alcohols and diamines respectively can be achieved using 3 equiv. sec-butyllithium–PMDETA in THF; use of n-butyllithium and (−)-sparteine in Et2O gave an alkynyl amino alcohol in 60% ee.

  二氢呋喃和二氢吡咯N-三异丙基苯磺酰氮丙啶分别直接转化为炔基氨基醇和二胺，可使用3当量的叔丁基锂-PMDETA在THF中实现；使用正丁基锂和（∘）-sparteine在Et2O中可得到60%ee的炔基氨基醇。