4-Methyl-2-(m-tolyl)thiazol | 103989-29-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Methyl-2-(m-tolyl)thiazol
• 英文别名: 4-methyl-2-m-tolyl-thiazole；4-Methyl-2-(3-methylphenyl)-1,3-thiazole
• CAS: 103989-29-3
• 化学式: C₁₁H₁₁NS
• mdl: MFCD16302930
• 分子量: 189.281
• InChiKey: VEDBZDPNJAQMRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Methyl-2-(m-tolyl)thiazol 在 selenium(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 Bis-<4-methyl-2-(m-tolyl)-thiazolyl-(5)>-selenid
  参考文献：
  名称：

  Asinger,F. et al., Justus Liebigs Annalen der Chemie, 1961, vol. 639, p. 133 - 146

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methyl-2-m-tolyl-2,5-dihydro-thiazole 在 sulfur 作用下， 反应 5.0h， 生成 4-Methyl-2-(m-tolyl)thiazol
  参考文献：
  名称：

  Asinger,F. et al., Justus Liebigs Annalen der Chemie, 1961, vol. 639, p. 133 - 146

  摘要：

  DOI：

文献信息

• Pd^II -Catalyzed Regio- and Enantioselective Oxidative C−H/C−H Cross-Coupling Reaction between Ferrocenes and Azoles
  作者：Zhong-Jian Cai、Chen-Xu Liu、Qing Gu、Chao Zheng、Shu-Li You

  DOI：10.1002/anie.201813887

  日期：2019.2.11

  Asymmetric C−H bond functionalization reaction is one of the most efficient and straightforward methods for the synthesis of optically active molecules. Herein we disclose an asymmetric C−H/C−H cross‐coupling reaction of ferrocenes with azoles such as oxazoles and thiazoles. Palladium(II)/monoprotected amino acid (MPAA) catalytic system which exhibits excellent reactivity and regioselectivity for oxazoles

  不对称CH键功能化反应是旋光分子合成中最有效，最直接的方法之一。在这里，我们公开了二茂铁与诸如恶唑和噻唑的唑的不对称CH / CH交叉偶联反应。钯（II）/单保护氨基酸（MPAA）催化体系，对恶唑和噻唑表现出出色的反应性和区域选择性。该方法为构建平面手性二茂铁提供了强有力的策略。机理研究表明，唑类化合物的CH键断裂很可能是通过S E Ar过程进行的，并且可能不是营业额限制步骤。
• Pd/Cu-cocatalyzed reigoselective arylation of thiazole derivatives at 2-position under ligand-free conditions
  作者：Jian Gu、Chun Cai

  DOI：10.1039/c5ra08703a

  日期：——

  regioselective arylation of thiazole derivatives at the 2-position via palladium- and copper-catalyzed C–H bond activation under ligand-free conditions has been developed. The reaction proceeds smoothly with 1% palladium catalyst in the presence of 20% Cu(TFA)2 to furnish the desired products. The direct C–H arylation and no ligand made this method synthetically useful for the arylation of thiazoles

  在无配体条件下，通过钯和铜催化的CH键的活化，可以有效地合成噻唑衍生物在2-位上的区域选择性芳基化反应。在20％Cu（TFA）2的存在下，使用1％钯催化剂可以使反应平稳进行，以提供所需的产物。直接的C–H芳基化反应且没有配体使该方法可用于2位噻唑的芳基化反应。
• Pd-Catalyzed Asymmetric Oxidative C–H/C–H Cross-Coupling Reaction between Ferrocenes and Azoles
  作者：Feifei Cao、Yanjiao Wang、Pengcheng Feng、Jianfeng Hu、Yong Yang、Hao Zhang

  DOI：10.1021/acs.joc.3c00212

  日期：2023.5.5

  The asymmetric C–H bond functionalization reaction is one of the most efficient and straightforward methods for the synthesis of optically active molecules. Herein, our work discovered a Pd-catalyzed asymmetric oxidative C–H/C–H cross-coupling reaction of ferrocenes with azoles such as oxazoles and thiazoles. Mono-N-protected amino acid as chiral ligands with palladium(II) has been demonstrated as

  不对称 C-H 键功能化反应是合成光学活性分子最有效和最直接的方法之一。在此，我们的工作发现了 Pd 催化的二茂铁与唑类如恶唑和噻唑的不对称氧化 C-H/C-H 交叉偶联反应。单-N-保护氨基酸作为手性配体与钯 (II) 已被证明是弱吖嗪导向的不对称 C-H 键功能化反应中的有效催化体系。该方法提供了一种强大的策略，可在温和条件下以中等产率（高达 70%）和良好的对映选择性（高达 95.3:4.7 er）通过双 C-H 键激活途径构建各种取代的平面手性二茂铁。
• Optical film, and polarizing plate and liquid crystal display device using the same
  申请人：Nagai Michio

  公开号：US20070065601A1

  公开（公告）日：2007-03-22

  An optical film comprising an optically anisotropic layer including a liquid crystalline compound, wherein the optically anisotropic layer satisfies the following formulae: Re (450)/ Re (650)<1.25  Formula (1): wherein Re(450) and Re(650) are in-plane retardation values (unit: nm) of the optically anisotropic layer at wavelengths of 450 nm and 650 nm, respectively; 0.09< Re — m (550)/ d Formula (2): wherein Re_m(550) is an in-plane retardation value (unit: nm) of a uniaxial alignment layer in which the director of the liquid crystalline compound is aligned to be parallel in the plane at a wavelength of 550 nm, and d is the thickness of the uniaxial alignment layer (unit: nm).
• Optical Compensation Film, Polarizing Plate and Liquid Crystal Display Device
  申请人：Matsubara Ryota

  公开号：US20090091690A1

  公开（公告）日：2009-04-09

  The present invention aims to provide an optical compensation film that allows superior phase difference between a first optically anisotropic layer and a second optically anisotropic layer and excellent wavelength dispersibility in terms of front and inclined retardation of liquid crystal layers in liquid crystal cells, a polarizing plate containing the optical compensation film, and a liquid-crystal display device that can display superior images with less color change due to the polarizing plate. In order to attain the object, an optical compensation film etc. is provided that comprises at least a first optically anisotropic layer and a second optically anisotropic layer, wherein the first optically anisotropic layer satisfies at least one of the following Equations (i) to (iii): 1≦ Re 1 450(0°)/ Re 1 650(0°)≦1.25:  Equation (i) 1≦ Re 1 450(40°)/ Re 1 650(40°)≦1.25:  Equation (ii) 1≦ Re 1 450(−40°)/ Re 1 650(−40°)≦1.25:  Equation (iii)