6-[(4-methoxybenzylidene)amino]-5-hydroxy-5-morpholin-4-yl-2,3,5,6-tetrahydro-1H-pyrrolizine-7-carbonitrile | 1338079-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 6-[(4-methoxybenzylidene)amino]-5-hydroxy-5-morpholin-4-yl-2,3,5,6-tetrahydro-1H-pyrrolizine-7-carbonitrile
• 英文别名: 3-Hydroxy-2-[(4-methoxyphenyl)methylideneamino]-3-morpholin-4-yl-2,5,6,7-tetrahydropyrrolizine-1-carbonitrile；3-hydroxy-2-[(4-methoxyphenyl)methylideneamino]-3-morpholin-4-yl-2,5,6,7-tetrahydropyrrolizine-1-carbonitrile
• CAS: 1338079-02-9
• 化学式: C₂₀H₂₄N₄O₃
• 分子量: 368.436
• InChiKey: RGEUSOPBSSGWNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-[(4-methoxybenzylidene)amino]-5-hydroxy-5-morpholin-4-yl-2,3,5,6-tetrahydro-1H-pyrrolizine-7-carbonitrile 、 巯基乙酸 在 溶剂黄146 作用下， 以 苯 为溶剂， 反应 24.0h， 以65%的产率得到6-[2-(4-methoxyphenyl)-4-oxo-thiazolidine-3-yl]-5-hydroxy-5-morpholin-4-yl-2,3,5,6-tetrahydro-1Hpyrrolizine-7-carbonitrile
  参考文献：
  名称：

  Synthesis and antitumor evaluation of some novel pyrrolizine derivatives

  摘要：

  Novel series of pyrrolizines (7, 9a-d, 10a-d, 11a, b, 14a-d, 16, 19, 20a, b, 24, 25a, b), pyrimido[5,4-a]pyrrolizines (12a, b, 13, 15a, b, 18, 21a, b, 22, 23a-d) and pyrido[3,2-a]pyrrolizines (17, 26a, b) were synthesized through different reactions. The chemical structures of all the synthesized pyrrolizine derivatives were determined by spectral and elemental analyses. Antitumor activity evaluation of all the prepared compounds was carried out using NR assay method against breast cancer cell line (MCF-7). The novel pyrrolizine scaffold 7 and all its prepared derivatives showed high antitumor activity comparable to that of doxorubicin.

  DOI：

  10.1007/s00044-011-9761-7
• 作为产物：
  描述：

  2-pyrrolidin-2-ylidene-malononitrile 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 48.0h， 生成 6-[(4-methoxybenzylidene)amino]-5-hydroxy-5-morpholin-4-yl-2,3,5,6-tetrahydro-1H-pyrrolizine-7-carbonitrile
  参考文献：
  名称：

  Synthesis and antitumor evaluation of some novel pyrrolizine derivatives

  摘要：

  Novel series of pyrrolizines (7, 9a-d, 10a-d, 11a, b, 14a-d, 16, 19, 20a, b, 24, 25a, b), pyrimido[5,4-a]pyrrolizines (12a, b, 13, 15a, b, 18, 21a, b, 22, 23a-d) and pyrido[3,2-a]pyrrolizines (17, 26a, b) were synthesized through different reactions. The chemical structures of all the synthesized pyrrolizine derivatives were determined by spectral and elemental analyses. Antitumor activity evaluation of all the prepared compounds was carried out using NR assay method against breast cancer cell line (MCF-7). The novel pyrrolizine scaffold 7 and all its prepared derivatives showed high antitumor activity comparable to that of doxorubicin.

  DOI：

  10.1007/s00044-011-9761-7

文献信息

• Synthesis and antitumor evaluation of some novel pyrrolizine derivatives
  作者：Mona M. Hanna、Nagwa M. Abdelgawad、Nashwa A. Ibrahim、Amany B. Mohammed

  DOI：10.1007/s00044-011-9761-7

  日期：2012.9

  Novel series of pyrrolizines (7, 9a-d, 10a-d, 11a, b, 14a-d, 16, 19, 20a, b, 24, 25a, b), pyrimido[5,4-a]pyrrolizines (12a, b, 13, 15a, b, 18, 21a, b, 22, 23a-d) and pyrido[3,2-a]pyrrolizines (17, 26a, b) were synthesized through different reactions. The chemical structures of all the synthesized pyrrolizine derivatives were determined by spectral and elemental analyses. Antitumor activity evaluation of all the prepared compounds was carried out using NR assay method against breast cancer cell line (MCF-7). The novel pyrrolizine scaffold 7 and all its prepared derivatives showed high antitumor activity comparable to that of doxorubicin.