3-(2,4-二甲基苯基)丙烷-1-醇 | 27650-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(2,4-二甲基苯基)丙烷-1-醇
• 英文名称: 3-(2,4-dimethylphenyl)propan-1-ol
• 英文别名: 3-(2,4-dimethylphenyl)propanol；1-[2.4]xylyl-propanol-(3)；3-Hydroxy-1-(2.4-dimethyl-phenyl)-propan；γ-(2,4-Xylyl)-propanol
• CAS: 27650-80-2
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: HFIRQLQQPJWFGZ-UHFFFAOYSA-N

物化性质

• 沸点：
  126 °C(Press: 5 Torr)
• 密度：
  0.972±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  3-(2,4-二甲基苯基)丙烷-1-醇 在 乙醇 、 氢溴酸 、 溶剂黄146 作用下， 生成 4-(2,4-二甲基-苯基)-丁酸酰胺
  参考文献：
  名称：

  CCCXXXV.—烷基萘的合成。第二部分 1：3：5和1：3：8-三甲基萘

  摘要：

  DOI：

  10.1039/jr9300002537
• 作为产物：
  描述：

  3-对甲苯丙烷-1-醇 在 palladium on activated charcoal 三氯化铝 、 氢气 、 对甲苯磺酸 、 lithium bromide 作用下， 以 乙醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 3.0~25.0 ℃ 、101.33 kPa 条件下， 反应 31.0h， 生成 3-(2,4-二甲基苯基)丙烷-1-醇
  参考文献：
  名称：

  1,3,4,5-四氢-2-苯并二恶英衍生物的合成，作为构形受限的仙客来醛类化合物，以及高气味活性同系物的中间体

  摘要：

  已制备了九种1,3,4,5-四氢-2-苯并二恶英衍生物，以模拟仙客来醛（1）及其相关化合物的折叠（gauche）构象，但它们均未显示出典型的铃兰（气味）。然而，将这些物质转化为先前未知的类似物1，该类似物在芳环的侧链的邻位具有Me取代基，从而产生了具有显着性能的新的芳香物质。结果表明，扩展的（抗）构象更有可能是在受体位点的“生物活性”构象。

  DOI：

  10.1002/hlca.19960790418

文献信息

• LOW VISCOSITY LOW VOLATILITY LUBRICATING OIL BASE STOCKS AND METHODS OF USE THEREOF
  申请人：ExxonMobil Research and Engineering Company

  公开号：US20170183595A1

  公开（公告）日：2017-06-29

  A lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. The lubricating oil base stock has a high temperature high shear (HTHS) viscosity of less than about 1.7 cP as determined by ASTM D4683, and a Noack volatility from about 15 to about 90 percent as determined by ASTM D5800. A lubricating oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. A method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein.

  一种润滑油基础油，包括根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯。该润滑油基础油的高温高剪切（HTHS）粘度小于约1.7厘泊，由ASTM D4683确定，挥发性从约15%到约90%，由ASTM D5800确定。一种含有根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯的润滑油基础油的润滑油。一种通过使用包含根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯的润滑油基础油的配制油来改善润滑油中的热稳定性、氧化稳定性、溶解性和分散性、沉积控制和牵引控制的方法。
• [EN] HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE<br/>[FR] COMPOSES HETEROCYCLIQUES, LEUR PREPARATION ET UTILISATION
  申请人：NOVO NORDISK A/S

  公开号：WO1994020495A1

  公开（公告）日：1994-09-15

  (EN) The present invention relates to therapeutically active azabicyclic compounds of Formula (1), wherein Z1 is oxygen or sulphur; a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.(FR) L'invention concerne des composés azabicycliques thérapeutiquement actifs, un procédé permettant de les préparer et des compositions pharmaceutiques les comprenant. Ces nouveaux composés servent à stimuler la fonction cognitive du prosencéphale et de l'hippocampe des mammifères, dans notamment le traitement de la maladie d'Alzheimer, des états fortement douloureux et du glaucome.

  (中文) 本发明涉及公式（1）的治疗活性的氮杂双环化合物，其中Z1是氧或硫；一种制备它们的方法以及包含这些化合物的制药组合物。这些新化合物可用作哺乳动物前脑和海马的认知功能的刺激剂，特别适用于治疗阿尔茨海默病、严重疼痛症和青光眼。
• 5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES
  申请人：Aissaoui Hamed

  公开号：US20100093740A1

  公开（公告）日：2010-04-15

  The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I), wherein X represents CH 2 or O; R 1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R 2 represents (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 2-4 )alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR 5 R 6 or cyclopropyl; R 3 represents (C 1-4 )alkyl, (C 1-4 )alkoxy-methyl or halogen; R 4 represents (C 1-4 )alkyl; R 5 represents hydrogen or (C 1-4 )alkyl; and R 6 represents hydrogen or (C 1-4 )alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

  本发明涉及公式（I）的5,6,7,8-四氢咪唑[1,5-a]吡嗪衍生物，其中X代表CH2或O; R1代表苯基，该基团独立地单取代、双取代或三取代，其中取代基独立地选自由（C1-4）烷基，（C1-4）烷氧基，卤素，氰基，三氟甲氧基和三氟甲基的群组; R2代表（C1-4）烷基，（C1-4）烷氧基，（C2-4）烯基，卤素，氰基，羟甲基，三氟甲基，C（O）NR5R6或环丙基; R3代表（C1-4）烷基，（C1-4）烷氧甲基或卤素; R4代表（C1-4）烷基; R5代表氢或（C1-4）烷基; R6代表氢或（C1-4）烷基。本发明还涉及这种化合物的药学上可接受的盐;以及将这种化合物用作药物的用途;特别是作为促进睡眠激素受体拮抗剂。
• Low viscosity low volatility lubricating oil base stocks and methods of use thereof
  申请人：ExxonMobil Research and Engineering Company

  公开号：US10077409B2

  公开（公告）日：2018-09-18

  A lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. The lubricating oil base stock has a high temperature high shear (HTHS) viscosity of less than about 1.7 cP as determined by ASTM D4683, and a Noack volatility from about 15 to about 90 percent as determined by ASTM D5800. A lubricating oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. A method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein.

  一种润滑油基础油，包括一种或多种由本文定义的式 (I)、(II)、(III) 和 (IV) 所代表的单酯。根据 ASTM D4683 测定，该润滑油基础油的高温高剪切 (HTHS) 粘度小于约 1.7 cP，根据 ASTM D5800 测定，该润滑油基础油的 Noack 挥发性介于约 15% 与约 90% 之间。一种润滑油，其润滑油基础油包括一种或多种由本文定义的式 (I)、(II)、(III) 和 (IV) 所代表的单酯。一种用于改善润滑油的热稳定性和氧化稳定性、极性添加剂的溶解性和分散性、沉积物控制和牵引力控制中的一项或多项性能的方法，其方法是将含有由本文定义的式 (I)、(II)、(III) 和 (IV) 所代表的一种或多种单酯的润滑油基础油用作润滑油。
• 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 6. trans-6-[2-(Substituted-1-naphthyl)ethyl(or ethenyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones
  作者：John D. Prugh、Alfred W. Alberts、Albert A. Deana、James L. Gilfillian、Jesse W. Huff、Robert L. Smith、J. Mark Wiggins

  DOI：10.1021/jm00164a047

  日期：1990.2

  A variety of trans-6-[2-(substituted-1-naphthyl)ethyl(or ethenyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones were prepared and, upon conversion to their 3,5-dihydroxy carboxylates, were found to have good inhibitory activity against the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-determining enzyme in cholesterogenesis. The most active compounds are 2,4,6- and 2,4,7-trichloro derivatives and would be expected to display about the same potency as the standard compactin upon resolution.