5-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)-4-imidazolin-2-one | 521092-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)-4-imidazolin-2-one
• 英文别名: 4-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)-1H-imidazol-2-one
• CAS: 521092-30-8
• 化学式: C₁₄H₉ClFN₃O
• 分子量: 289.696
• InChiKey: HCXOCPBPXCCSNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯异烟酸 在 盐酸羟胺 、 sodium acetate 、 sodium 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 9.0h， 生成 5-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)-4-imidazolin-2-one
  参考文献：
  名称：

  4-IMIDAZOLIN-2-ONE COMPOUNDS AS p38 MAP KINASE INHIBITORS

  摘要：

  公开号：

  EP1439174B1

文献信息

• 4-Imidazolin-2-one compounds
  申请人：——

  公开号：US20040204426A1

  公开（公告）日：2004-10-14

  The present invention relates to a compound of the formula [I]: 1 wherein G 1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: 2 wherein ring B is benzene ring which may be substituted, etc., Q 1 and Q 2 maybe the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, R 1 is hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z 1 , Z 2 , Z 3 and Z 4 may be the same or different, and each is CH or N, provided that 3 or more of Z 1 , Z 2 , Z 3 and Z 4 should not be N at the same time, G 2 is hydrogen atom, —NR 3 R 4 , —OR 5 , etc., where R 3 to R 8 each is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.

  本发明涉及一种式为[I]的化合物：1其中G1是被卤素原子或烷氧基取代的烷基，或者是公式2的基团：其中环B是苯环，可以取代等；Q1和Q2可能相同或不同，且每个都是氢原子、卤素原子或烷基；n为0、1、2、3或4；R1是氢原子、可取代的烷基、可取代的环烷基、可取代的苯基等；Z1、Z2、Z3和Z4可能相同或不同，每个都是CH或N，但要求Z1、Z2、Z3和Z4中的3个或更多个不能同时为N；G2是氢原子、—NR3R4、—OR5等，其中R3到R8各自独立地是氢原子、可取代的烷基、烯基、炔基等；或其药学上可接受的盐。
• 4-IMIDAZOLIN-2-ONE COMPOUNDS
  申请人：Kubo Akira

  公开号：US20090088422A1

  公开（公告）日：2009-04-02

  The present invention relates to a compound of the formula [I]: wherein G 1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: wherein ring B is benzene ring which may be substituted, etc., Q1 and Q2 may be the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, R 1 is hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z 1 , Z 2 , Z 3 and Z 4 may be the same or different, and each is CH or N, provided that 3 or more of Z 1 , Z 2 , Z 3 and Z 4 should not be N at the same time, G 2 is hydrogen atom, —NR 3 R 4 , —OR 5 , etc., where R 3 to R 8 each is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.

  本发明涉及一种式[I]的化合物：其中，G1是被卤素原子或烷氧基取代的烷基，或者是式的基团：其中环B是苯环，可能被取代等，Q1和Q2可以相同也可以不同，且每个是氢原子、卤素原子或烷基，n为0、1、2、3或4，R1是氢原子、可能被取代的烷基、可能被取代的环烷基、可能被取代的苯基等，Z1、Z2、Z3和Z4可以相同也可以不同，且每个是CH或N，但应满足Z1、Z2、Z3和Z4中至少有3个不为N，G2是氢原子、-NR3R4、-OR5等，其中R3至R8各自独立地是氢原子、可能被取代的烷基、烯基、炔基等，或者其药学上可接受的盐。
• EP1628968A4
  申请人：——

  公开号：EP1628968A4

  公开（公告）日：2008-03-05
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Sheridan Joseph M.

  公开号：US20140031547A1

  公开（公告）日：2014-01-30

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Electrophoretics Limited

  公开号：US20160354375A1

  公开（公告）日：2016-12-08

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.