A composition for use in the treatment of the human or animal body by reducing post-surgical adhesion formation/reformation following surgical injury to mammalian peritoneal or pleural cavity tissue or organs situated therein which comprises a polyoxyalkylene block copolymer of the formula:
Y[(A)E―H]x (I)
wherein A is an oxyalkylene moiety having an oxygen/carbon atom ratio of less than 0.5, x is at least 1 Y is derived from water or an organic compound containing x reactive hydrogen atoms, E is a polyoxyethylen moiety, n has a value such that the average molecular weight of A is at least about 500 to about 900, as determined by the hydroxyl number of an intermediate,
Y[(A)―H]x (II)
and the total average molecular weight of the copolymer is at least 5000.
一种用于治疗人或动物身体的组合物,可在哺乳动物腹膜或胸膜腔组织或其中的器官受到手术损伤后,减少手术后粘连的形成/
重组,该组合物包括式中的聚氧亚烷基嵌段共聚物:
Y[(A)E-H]x (I)
其中 A 是氧原子/碳原子比小于 0.5 的氧亚烃分子,x 至少为 1,Y 来自
水或含有 x 个活性氢原子的有机化合物,E 是聚氧
乙烯分子,n 的值为根据中间体的羟基数确定的 A 的平均分子量至少约为 500 至约 900、
Y[(A)-H]x (II)
共聚物的总平均分子量至少为 5000。