Boc-D-Phe-DL-Gly(PO(OMe)2)-OMe | 643090-89-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-D-Phe-DL-Gly(PO(OMe)2)-OMe
• 英文别名: methyl 2-dimethoxyphosphoryl-2-[[(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]acetate
• CAS: 643090-89-5
• 化学式: C₁₉H₂₉N₂O₈P
• 分子量: 444.422
• InChiKey: HNZHJEBKDLKFRV-IURRXHLWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Boc-D-Phe-DL-Gly(PO(OMe)2)-OMe 在 lithium aluminium tetrahydride 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 N-Boc-D-Phe-ΔTyr(OTIPS)-CH2OH
  参考文献：
  名称：

  Synthetic approaches to the southern part of cyclotheonamide C

  摘要：

  A synthetic equivalent of the Southern segment of cyclotheonamide C, a cyclopentapeptide isolated from the sponge Theonella, has been synthesized via complementary Wadsworth-Emmons or palladium-catalysed methodologies followed by tandem oxidation/vinylogation in 41% overall yield (five steps) front readily available starting materials. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.196
• 作为产物：
  描述：

  (±)-Z-α-膦酰甘氨酸三甲酯 在 palladium on activated charcoal 氢气 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、303.98 kPa 条件下， 生成 Boc-D-Phe-DL-Gly(PO(OMe)2)-OMe
  参考文献：
  名称：

  Synthetic approaches to the southern part of cyclotheonamide C

  摘要：

  A synthetic equivalent of the Southern segment of cyclotheonamide C, a cyclopentapeptide isolated from the sponge Theonella, has been synthesized via complementary Wadsworth-Emmons or palladium-catalysed methodologies followed by tandem oxidation/vinylogation in 41% overall yield (five steps) front readily available starting materials. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.196

文献信息

• Synthetic approaches to the southern part of cyclotheonamide C
  作者：David J. Aitken、Sophie Faure、Stéphane Roche

  DOI：10.1016/j.tetlet.2003.09.196

  日期：2003.12

  A synthetic equivalent of the Southern segment of cyclotheonamide C, a cyclopentapeptide isolated from the sponge Theonella, has been synthesized via complementary Wadsworth-Emmons or palladium-catalysed methodologies followed by tandem oxidation/vinylogation in 41% overall yield (five steps) front readily available starting materials. (C) 2003 Elsevier Ltd. All rights reserved.