Boc-D-Phe-DL-Ser-OMe | 643090-90-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-D-Phe-DL-Ser-OMe
• 英文别名: methyl 3-hydroxy-2-[[(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]propanoate
• CAS: 643090-90-8
• 化学式: C₁₈H₂₆N₂O₆
• 分子量: 366.414
• InChiKey: TXPSDTDXSCHBJF-KWCCSABGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Boc-D-Phe-DL-Ser-OMe 在 N-溴代丁二酰亚胺(NBS) 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 copper(l) chloride 作用下， 以 二氯甲烷 为溶剂， 生成 Boc-D-Phe-Dha(Br)-OMe
  参考文献：
  名称：

  Synthetic approaches to the southern part of cyclotheonamide C

  摘要：

  A synthetic equivalent of the Southern segment of cyclotheonamide C, a cyclopentapeptide isolated from the sponge Theonella, has been synthesized via complementary Wadsworth-Emmons or palladium-catalysed methodologies followed by tandem oxidation/vinylogation in 41% overall yield (five steps) front readily available starting materials. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.196
• 作为产物：
  描述：

  2-氨基-3-羟基丙酸甲酯 、 Boc-D-苯丙氨酸 在 三乙胺 、 氯甲酸异丁酯 作用下， 以 二氯甲烷 为溶剂， 以87%的产率得到Boc-D-Phe-DL-Ser-OMe
  参考文献：
  名称：

  Synthetic approaches to the southern part of cyclotheonamide C

  摘要：

  A synthetic equivalent of the Southern segment of cyclotheonamide C, a cyclopentapeptide isolated from the sponge Theonella, has been synthesized via complementary Wadsworth-Emmons or palladium-catalysed methodologies followed by tandem oxidation/vinylogation in 41% overall yield (five steps) front readily available starting materials. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.196

文献信息

• Synthetic approaches to the southern part of cyclotheonamide C
  作者：David J. Aitken、Sophie Faure、Stéphane Roche

  DOI：10.1016/j.tetlet.2003.09.196

  日期：2003.12

  A synthetic equivalent of the Southern segment of cyclotheonamide C, a cyclopentapeptide isolated from the sponge Theonella, has been synthesized via complementary Wadsworth-Emmons or palladium-catalysed methodologies followed by tandem oxidation/vinylogation in 41% overall yield (five steps) front readily available starting materials. (C) 2003 Elsevier Ltd. All rights reserved.