4-[5-(carboxy)pentylamino]-1-(benzyloxy)pyrimidin-2(1H)-one | 189497-21-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-[5-(carboxy)pentylamino]-1-(benzyloxy)pyrimidin-2(1H)-one
• 英文别名: 4-[(5-carboxypentyl)amino]-1-(benzyloxy)-2(1H)-pyrimidinone；6-[(2-Oxo-1-phenylmethoxypyrimidin-4-yl)amino]hexanoic acid
• CAS: 189497-21-0
• 化学式: C₁₇H₂₁N₃O₄
• 分子量: 331.371
• InChiKey: IBTXAVMRKNQXRU-UHFFFAOYSA-N

物化性质

• 沸点：
  515.5±60.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  91.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[5-(carboxy)pentylamino]-1-(benzyloxy)pyrimidin-2(1H)-one 在 palladium on activated charcoal WSC*HCl 、 氢气 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 63.0h， 生成 tris(2-{6-[1-(1-hydroxy-2-oxo-1,2-dihydropyrimidin-4-yl)amino]hexanamido}ethyl)amine
  参考文献：
  名称：

  Novel Iron Sequestering Agents:  Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1H)-pyrimidinone, ω-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine

  摘要：

  Novel heterocyclic hexadentate ligands (3HOPY(n): n = 5-7), in which three units of 1-hydroxy-2(1H)-pyrimidinone are linked to tris(2-aminoethyl)amine through an amide bond by an alkyl chain, were synthesized, and their iron-chelating properties were investigated. The stability of their iron complexes (25 to 27 in log K) was significantly larger than that of pyrazinone-containing ligands by virtue of higher pK(a) values. On kinetic evaluation of iron removal from human transferrin, 3HOPY(5) showed remarkable efficiency over five times as much as commercially available desferrioxamine B. The conformational analysis of the corresponding Ga(III) complex of Fe(opy(5)) by H-1 NMR and by MM and MD calculations are also discussed.

  DOI：

  10.1021/jo961901m
• 作为产物：
  描述：

  N-(苄氧基)脲 在 sodium hydroxide 、 sodium 、 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 乙腈 为溶剂， 反应 107.0h， 生成 4-[5-(carboxy)pentylamino]-1-(benzyloxy)pyrimidin-2(1H)-one
  参考文献：
  名称：

  Novel Iron Sequestering Agents:  Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1H)-pyrimidinone, ω-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine

  摘要：

  Novel heterocyclic hexadentate ligands (3HOPY(n): n = 5-7), in which three units of 1-hydroxy-2(1H)-pyrimidinone are linked to tris(2-aminoethyl)amine through an amide bond by an alkyl chain, were synthesized, and their iron-chelating properties were investigated. The stability of their iron complexes (25 to 27 in log K) was significantly larger than that of pyrazinone-containing ligands by virtue of higher pK(a) values. On kinetic evaluation of iron removal from human transferrin, 3HOPY(5) showed remarkable efficiency over five times as much as commercially available desferrioxamine B. The conformational analysis of the corresponding Ga(III) complex of Fe(opy(5)) by H-1 NMR and by MM and MD calculations are also discussed.

  DOI：

  10.1021/jo961901m

文献信息

• Masuda, Takeshi; Hayashi, Jun-Ichiro; Tamagaki, Seizo, Journal of the Chemical Society. Perkin Transactions 2 (2001), 2000, # 1, p. 161 - 167
  作者：Masuda, Takeshi、Hayashi, Jun-Ichiro、Tamagaki, Seizo

  DOI：——

  日期：——
• Novel Iron Sequestering Agents:  Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1<i>H</i>)-pyrimidinone, ω-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine
  作者：Junko Ohkanda、Jun Kamitani、Takeshi Tokumitsu、Yoko Hida、Takeo Konakahara、Akira Katoh

  DOI：10.1021/jo961901m

  日期：1997.5.1

  Novel heterocyclic hexadentate ligands (3HOPY(n): n = 5-7), in which three units of 1-hydroxy-2(1H)-pyrimidinone are linked to tris(2-aminoethyl)amine through an amide bond by an alkyl chain, were synthesized, and their iron-chelating properties were investigated. The stability of their iron complexes (25 to 27 in log K) was significantly larger than that of pyrazinone-containing ligands by virtue of higher pK(a) values. On kinetic evaluation of iron removal from human transferrin, 3HOPY(5) showed remarkable efficiency over five times as much as commercially available desferrioxamine B. The conformational analysis of the corresponding Ga(III) complex of Fe(opy(5)) by H-1 NMR and by MM and MD calculations are also discussed.