4-methyl-6-ethyl-2,3-dihydrothieno[2,3-c]furan | 908239-73-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-methyl-6-ethyl-2,3-dihydrothieno[2,3-c]furan
• 英文别名: 6-Ethyl-4-methyl-2,3-dihydrothieno[2,3-c]furan
• CAS: 908239-73-6
• 化学式: C₉H₁₂OS
• 分子量: 168.26
• InChiKey: WGOVKGUWQDCYDW-UHFFFAOYSA-N

物化性质

• 沸点：
  230.261±39.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.123±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  38.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(噻吩-3-基)乙醇 在 Wilkinson's catalyst 甲醇 、 氢气 、 仲丁基锂 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 六氯乙烷 、 甲苯 为溶剂， -78.0~100.0 ℃ 、1.0 MPa 条件下， 反应 27.25h， 生成 4-methyl-6-ethyl-2,3-dihydrothieno[2,3-c]furan
  参考文献：
  名称：

  NOVEL THIOPHENE COMPOUND AND PROCESS FOR PRODUCING CAFFENOFURAN OR ANALOGUE THEREOF FROM THE SAME

  摘要：

  公开号：

  EP1854791B1

文献信息

• Novel Thiophene Compound and Process for Producing Caffenofuran or Analogue Thereof from the Same
  申请人：Katsumura Shigeo

  公开号：US20080167481A1

  公开（公告）日：2008-07-10

  The present invention provides a novel thiophene compound as a synthetic intermediate that is useful for efficient production of kahweofuran or an analogue thereof. The present invention also provides a process for producing kahweofuran or an analogue thereof using the novel thiophene compound as an intermediate material. Of novel thiophene compounds represented by Formula (1): wherein R 1 is a hydrogen atom or a C 1 -C 4 lower alkyl group; R 2 is a hydrogen atom or an alcohol-protecting group; R 3 is a hydrogen atom, —COR 4 or —C(OH)R 5 (wherein R 4 and R 5 each represent a C 1 -C 4 lower alkyl group); provided that when R 2 and R 3 are hydrogen atoms, R 1 is not any of a hydrogen atom, methyl group, or n-propyl group; a thiophene compound represented by Formula (2) is reduced and cyclized in the presence of a transition metal catalyst to produce kahweofuran or kahweofuran analogue (3 a ) shown below: wherein R 1 is a hydrogen atom or a C 1 -C 4 lower alkyl group, and R 4 is a C 1 -C 4 lower alkyl group.
• US7897790B2
  申请人：——

  公开号：US7897790B2

  公开（公告）日：2011-03-01
• NOVEL THIOPHENE COMPOUND AND PROCESS FOR PRODUCING CAFFENOFURAN OR ANALOGUE THEREOF FROM THE SAME
  申请人：SAN-EI GEN F.F.I., INC.

  公开号：EP1854791B1

  公开（公告）日：2011-07-13