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3-(2-羟乙基)环戊烷-1-醇 | 61478-09-9

中文名称
3-(2-羟乙基)环戊烷-1-醇
中文别名
——
英文名称
3-(2-hydroxyethyl)cyclopentanol
英文别名
2-(3-Hydroxycyclopentyl)-ethanol;3-(2-Hydroxyethyl)cyclopentan-1-ol
3-(2-羟乙基)环戊烷-1-醇化学式
CAS
61478-09-9
化学式
C7H14O2
mdl
——
分子量
130.187
InChiKey
RVOYBCULFYEQIT-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.4
  • 重原子数:
    9
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    1.0
  • 拓扑面积:
    40.5
  • 氢给体数:
    2
  • 氢受体数:
    2

反应信息

点击查看最新优质反应信息

文献信息

  • TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
    申请人:Arvinas, Inc.
    公开号:US20180155322A1
    公开(公告)日:2018-06-07
    The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, Inhibitors of Apoptosis Proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
    本公开涉及双功能化合物,这些化合物可用作雌激素受体(目标蛋白)的调节剂。特别是,本公开涉及包含在一段至少有一种Von Hippel-Lindau配体、一种cereblon配体、凋亡抑制蛋白配体、小鼠双分钟同源2配体或其组合的双功能化合物,这些配体与相应的E3泛素连接酶结合,在另一端有一个与目标蛋白结合的部分,使得目标蛋白被置于泛素连接酶附近,以实现目标蛋白的降解(和抑制)。本公开展示了与目标蛋白降解/抑制相关的广泛药理活性。可以通过本公开的化合物和组合物治疗或预防由目标蛋白聚集或积累引起的疾病或障碍。
  • Cerium or Ruthenium Catalyzed Oxidation of Alcohols to Carbonyl Compounds by Means of Sodium Bromate
    作者:Shigekazu Kanemoto、Hiroki Tomioka、Koichiro Oshima、Hitosi Nozaki
    DOI:10.1246/bcsj.59.105
    日期:1986.1
    alcohols in the presence of cerium or ruthenium compounds in biphase reaction. Selective oxidation of secondary alcohols was performed in the presence of primary ones using cerium(IV) ammonium nitrate (CAN) or cerium(IV) sulfate (CS) as catalyst. For instance, treatment of 1,10-undecanediol with CS/NaBrO3 provided 11-hydroxy-2-undecanone in 82% yield. Ruthenium catalyzed biphase oxidation of alcohols
    已发现溴酸钠是在双相反应中在铈或钌化合物存在下氧化醇的有效氧化剂。仲醇的选择性氧化在伯醇存在下使用硝酸铈 (IV) 铵 (CAN) 或硫酸铈 (IV) (CS) 作为催化剂进行。例如,用 CS/NaBrO3 处理 1,10-十一烷二醇以 82% 的产率提供 11-羟基-2-十一烷酮。钌催化醇与溴酸钠的双相氧化以良好至极好的产率提供相应的醛或酮。
  • Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
    申请人:Arvinas, Inc.
    公开号:US10647698B2
    公开(公告)日:2020-05-12
    The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, Inhibitors of Apoptosis Proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
    本公开涉及双功能化合物,它们可用作雌激素受体(靶蛋白)的调节剂。特别是,本公开涉及双功能化合物,其一端含有 Von Hippel-Lindau 配体、cereblon 配体、凋亡蛋白抑制剂配体、小鼠双敏同源物 2 配体或其组合中的至少一种、其一端与相应的 E3 泛素连接酶结合,另一端与靶蛋白结合,从而将靶蛋白置于泛素连接酶附近,以实现对靶蛋白的降解(和抑制)。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防因目标蛋白聚集或积聚而导致的疾病或失调。
  • Synthesis of 2-Quinuclidonium by Eliminating Water:  Experimental Quantification of the High Basicity of Extremely Twisted Amides
    作者:Tony Ly、Michael Krout、Don K. Pham、Kousuke Tani、Brian M. Stoltz、Ryan R. Julian
    DOI:10.1021/ja067703m
    日期:2007.2.1
    The chemical properties of an extremely twisted amide are examined quantitatively for the first time. The predicted high basicity of 2-quinuclidonium is confirmed experimentally by measuring the gas-phase proton affinity using the extended kinetic method. Fragmentation of this molecule further reveals that the lack of resonance stabilization weakens the amide bond. Furthermore, a new route for synthesizing 2-quinuclidonium by eliminating water is demonstrated in the gas phase.
  • NONAKA, TSUYOSHI;KANEMOTO, SHIGEKAZU;OSHIMA, KOICHIRO;NOZAKI, HITOSI, BULL. CHEM. SOC. JAP., 1984, 57, N 7, 2019-2020
    作者:NONAKA, TSUYOSHI、KANEMOTO, SHIGEKAZU、OSHIMA, KOICHIRO、NOZAKI, HITOSI
    DOI:——
    日期:——
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