3-(4-Methylpiperazino)-4,5-dihydro-2(3H)-furanon | 81413-28-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(4-Methylpiperazino)-4,5-dihydro-2(3H)-furanon
• 英文别名: 3-(4-Methylpiperazin-1-yl)oxolan-2-one
• CAS: 81413-28-7
• 化学式: C₉H₁₆N₂O₂
• 分子量: 184.238
• InChiKey: WUCWNFMVUTWGEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯基锂 、 3-(4-Methylpiperazino)-4,5-dihydro-2(3H)-furanon 以 乙醚 、 苯 为溶剂， 反应 12.0h， 以56%的产率得到1,1-Diphenyl-2-(4-methylpiperazino)-1,4-butandiol
  参考文献：
  名称：

  内酯，第 1 版。通过 α-氨基-γ-内酯合成二羟基二苯乙胺

  摘要：

  相应的 α-氨基-γ-内酯与苯基锂反应生成 2-氨基-1,1-二苯基-烷烃-1,4-二醇 2a – f，也可被视为二羟基二苯乙胺。

  DOI：

  10.1002/ardp.19823150309
• 作为产物：
  描述：

  N-甲基哌嗪 、 α-溴-γ-丁内酯 以 甲苯 为溶剂， 以58%的产率得到3-(4-Methylpiperazino)-4,5-dihydro-2(3H)-furanon
  参考文献：
  名称：

  内酯，第 1 版。通过 α-氨基-γ-内酯合成二羟基二苯乙胺

  摘要：

  相应的 α-氨基-γ-内酯与苯基锂反应生成 2-氨基-1,1-二苯基-烷烃-1,4-二醇 2a – f，也可被视为二羟基二苯乙胺。

  DOI：

  10.1002/ardp.19823150309

文献信息

• [EN] SUBSTITUTED PYRIMIDINES AND METHODS OF USE<br/>[FR] PYRIMIDINES SUBSTITUÉES ET MÉTHODES D'UTILISATION
  申请人：THERAVANCE BIOPHARMA R&D IP LLC

  公开号：WO2021203131A1

  公开（公告）日：2021-10-07

  The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

  本公开提供了抑制活性素受体样激酶5（ALK5）的抑制剂。还公开了调节ALK5活性的方法以及治疗由ALK5介导的疾病的方法。
• Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
  申请人：NEUROSEARCH A/S

  公开号：US20040097570A1

  公开（公告）日：2004-05-20

  The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABA A receptor complex, and in particular for inducing and maintaining anesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.

  本发明涉及新型苯并咪唑衍生物，包含这些化合物的制药组合物，以及使用它们的治疗方法。该发明的化合物在治疗对GABAA受体复合物调节有响应的中枢神经系统疾病和疾病方面具有用途，特别是用于诱导和维持麻醉、镇静和肌肉松弛，以及对儿童的热性惊厥进行抗击。该发明的化合物也可以被兽医使用。
• POLYMERS FUNCTIONALIZED WITH LACTONES OR THIOLACTONES CONTAINING A PROTECTED AMINO GROUP
  申请人：Bridgestone Corporation

  公开号：EP2751142A1

  公开（公告）日：2014-07-09
• PATTERN FORMING METHOD, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, RESIST FILM, MANUFACTURING METHOD OF ELECTRONIC DEVICE AND ELECTRONIC DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20140045117A1

  公开（公告）日：2014-02-13

  A pattern forming method, includes: (i) a step of forming a film from an actinic ray-sensitive or radiation-sensitive resin composition containing (P) a resin having (a1) a repeating unit capable of decomposing by an action of an acid to produce a carboxyl group, represented by the following formula (I) as defined in the specification and (B) a compound capable of generating an acid upon irradiation with an actinic ray or radiation; (ii) a step of exposing the film; and (iii) a step of performing a development by using a developer containing an organic solvent to form a negative pattern.
• ACTINIC RAY- OR RADIATION-SENSITIVE RESIN COMPOSITION, ACTINIC RAY- OR RADIATION-SENSITIVE FILM AND METHOD OF FORMING PATTERN
  申请人：FUJIFILM Corporation

  公开号：US20140234759A1

  公开（公告）日：2014-08-21

  According to one embodiment, there is provided an actinic ray- or radiation-sensitive resin composition containing (A) a resin containing a repeating unit represented by general formula (1) below and a repeating unit that is decomposed by an action of an acid to generate an alkali-soluble group, and (B) a compound that generates the acid when exposed to actinic rays or radiation, where L represents a bivalent connecting group, R 1 represents a hydrogen atom or an alkyl group, and Z represents a cyclic acid anhydride structure.