Ethyl 2-benzyl-3-(4-benzyl-5-morpholin-4-yl-1,3-oxazol-2-yl)-3-oxopropanoate | 1206197-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Ethyl 2-benzyl-3-(4-benzyl-5-morpholin-4-yl-1,3-oxazol-2-yl)-3-oxopropanoate
• 英文别名: ethyl 2-benzyl-3-(4-benzyl-5-morpholin-4-yl-1,3-oxazol-2-yl)-3-oxopropanoate
• CAS: 1206197-81-0
• 化学式: C₂₆H₂₈N₂O₅
• 分子量: 448.519
• InChiKey: HOTBZDZQDIDENY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  81.9
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-异氰基-1-吗啉-4-基-3-苯基丙烷-1-酮 、 ethyl 2-diazo-3-carbonyl-4-phenylbutyrate 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 4.0h， 以84%的产率得到Ethyl 2-benzyl-3-(4-benzyl-5-morpholin-4-yl-1,3-oxazol-2-yl)-3-oxopropanoate
  参考文献：
  名称：

  Synthesis of Polysubstituted 5-Aminooxazoles from α- Diazocarbonyl Esters and α-Isocyanoacetamides

  摘要：

  A novel and efficient reaction for the synthesis of 2-keto-5-aminooxazoles is developed. The entire sequence is realized by simply heating a xylene solution of alpha-diazocarbonyl esters and alpha-isocyanoacetamides without any promoters. A possible mechanism for the entire sequence is proposed.

  DOI：

  10.1021/ol902850a

文献信息

• Synthesis of Polysubstituted 5-Aminooxazoles from α- Diazocarbonyl Esters and α-Isocyanoacetamides
  作者：Jianwei Wu、Wenteng Chen、Miao Hu、Hongbin Zou、Yongping Yu

  DOI：10.1021/ol902850a

  日期：2010.2.5

  A novel and efficient reaction for the synthesis of 2-keto-5-aminooxazoles is developed. The entire sequence is realized by simply heating a xylene solution of alpha-diazocarbonyl esters and alpha-isocyanoacetamides without any promoters. A possible mechanism for the entire sequence is proposed.