1-[6-Methoxy-2,3-bis(4-methylphenyl)indol-1-yl]ethanone | 1332835-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[6-Methoxy-2,3-bis(4-methylphenyl)indol-1-yl]ethanone
• 英文别名: 1-[6-methoxy-2,3-bis(4-methylphenyl)indol-1-yl]ethanone
• CAS: 1332835-82-1
• 化学式: C₂₅H₂₃NO₂
• 分子量: 369.463
• InChiKey: OMZBUUWDYIXWRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  间氨基苯甲醚 在 palladium diacetate 、 copper(II) bis(trifluoromethanesulfonate) 、 silver(l) oxide 作用下， 以 二氯甲烷 、 N,N-二甲基乙酰胺 为溶剂， 反应 4.0h， 生成 1-[6-Methoxy-2,3-bis(4-methylphenyl)indol-1-yl]ethanone
  参考文献：
  名称：

  Synthesis of indoles via palladium-catalyzed C–H activation of N-aryl amides followed by coupling with alkynes

  摘要：

  A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.009

文献信息

• Synthesis of indoles via palladium-catalyzed C–H activation of N-aryl amides followed by coupling with alkynes
  作者：Feng Zhou、Xiuling Han、Xiyan Lu

  DOI：10.1016/j.tetlet.2011.07.009

  日期：2011.9

  A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved. (C) 2011 Elsevier Ltd. All rights reserved.