甲基丙烯酸四氢糠基酯 | 2455-24-5

• 物质功能分类: 催化剂及助剂 - 塑料橡胶助剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 中文名称: 甲基丙烯酸四氢糠基酯
• 中文别名: 甲基丙烯酸四氢呋喃酯；2-甲基-2-丙烯酸(四氢-2-呋喃基)甲酯；甲基丙烯酸四氢糠酯；甲基丙烯酸氢糠酯
• 英文名称: (tetrahydrofuran-2-yl)methyl 2-methylprop-2-enoate
• 英文别名: tetrahydrofurfuryl methacrylate；THFMA；methacrylic acid tetrahydrofurfuryl ester；Methacrylsaeure-tetrahydrofurfurylester；2-methyl-2-propenoic acid, (tetrahydro-2-furanyl)methyl ester；2-methyl-propenoic acid tetrahydrofuranyl-methyl ester；oxolan-2-ylmethyl 2-methylprop-2-enoate
• CAS: 2455-24-5
• 化学式: C₉H₁₄O₃
• mdl: MFCD00014515
• 分子量: 170.208
• InChiKey: LCXXNKZQVOXMEH-UHFFFAOYSA-N

物化性质

• 沸点：
  52 °C0.4 mm Hg(lit.)
• 密度：
  1.044 g/mL at 25 °C(lit.)
• 闪点：
  195 °F
• LogP：
  1.76 at 22.6℃
• 物理描述：
  Liquid
• 稳定性/保质期：

  在常温常压下保持稳定，需避免与氧化物接触，并尽量减少光的直接照射。

• 聚合：
  METHYL METHACRYLATE, AND IN GENERAL THE METHACRYLIC ESTERS, POLYMERIZE MUCH LESS READILY THAN THE CORRESPONDING ORDINARY ACRYLATES. NONE THE LESS, THEY ARE STABILIZED BY ADDING HYDROQUINONE OR PYROGALLOL, PARTICULARLY IN THE PRESENCE OF METALLIC COPPER. /METHACRYLATES/
• 折光率：
  Index of refraction: 1.4552 at 20 °C/D

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

少量的甲基丙烯酸酯可以通过皂化作用轻易地代谢成醇和甲基丙烯酸。后者可以形成乙酰辅酶A衍生物，然后进入正常的脂质代谢。/甲基丙烯酸酯/

SMALL QUANTITIES OF METHACRYLATES MAY READILY BE METABOLIZED BY SAPONIFICATION INTO THE ALCOHOL AND METHACRYLIC ACID. THE LATTER MAY FORM AN ACETYL-COENZYME A DERIVATIVE, WHICH THEN ENTERS THE NORMAL LIPID METABOLISM. /METHACRYLATES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

皮肤致敏剂 - 一种可以诱导皮肤产生过敏反应的制剂。

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要进行治疗……。监测休克，如有必要进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的咳嗽反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……。/酯类及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊阀面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。开始静脉输液，使用D5W TKO /SRP：“保持开放”，最低流速。如果出现低血容量的迹象，使用乳酸钠林格氏液。注意液体过载的迹象。对于伴有低血容量迹象的低血压，谨慎给予液体。如果病人在正常液体容量下出现低血压，考虑使用血管加压药。注意液体过载的迹象。考虑使用药物治疗肺水肿。使用丙美卡因氢氯化物协助眼部冲洗。/酯类及相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Consider drug therapy for pulmonary edema ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

生物上，甲基丙烯酸酯类似于丙烯酸酯，但反应性较低，因此毒性降低。这可能是由于其甲基基团的空间位阻，从而降低了膜传输和系统转移的速率。/甲基丙烯酸酯/

BIOLOGICALLY, METHACRYLATES RESEMBLE ACRYLATES, EXCEPT FOR LOWER REACTIVITY & THUS DECR TOXICITY. THIS IS PROBABLY DUE TO STERIC HINDRANCE BY ITS METHYL GROUP & IN TURN DECR RATES OF MEMBRANE TRANSPORT & SYSTEMIC TRANSLOCATION. /METHACRYLIC ESTERS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

二十一种不同的丙烯酸和甲基丙烯酸化合物，包括四氢呋喃基甲基丙烯酸酯，被扫描以检测它们引发接触敏感性的能力，使用了5种不同的致敏方案。对所有测试的单体、二体和三丙烯酸酯产生了不同程度的接触反应。甲基丙烯酸酯没有致敏豚鼠。

TWENTY-ONE DIFFERENT ACRYLATE & METHACRYLATE COMPOUNDS, INCLUDING TETRAHYDROFURFURYL METHACRYLATE, WERE SCANNED FOR THEIR ABILITY TO INDUCE CONTACT SENSITIVITY, USING 5 DIFFERENT SENSITIZATION PROTOCOLS. CONTACT REACTIONS OF VARYING INTENSITIES WERE PRODUCED TO ALL THE MONO-, DI-, AND TRIACRYLATES TESTED. METHACRYLATES DID NOT SENSITIZE GUINEA PIGS.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• TSCA：
  Yes
• 危险等级：
  3
• 危险类别码：
  R10,R36/37/38
• 危险品运输编号：
  3272
• WGK Germany：
  1
• 海关编码：
  2932190090
• 包装等级：
  III
• 危险类别：
  3
• 安全说明：
  S36
• 危险性防范说明：
  P264,P280,P302+P352+P332+P313+P362+P364,P305+P351+P338+P337+P313
• 危险性描述：
  H315,H319
• 储存条件：
  请将容器密封后，放入一个紧密的储存器中，并存放在阴凉、干燥的地方。

SDS

Tetrahydrofurfuryl Methacrylate (stabilized with MEHQ) Revision number: 5
SAFETY DATA SHEET

---

Section 1. IDENTIFICATION
Product name: Tetrahydrofurfuryl Methacrylate (stabilized with MEHQ)

Revision number: 5

---

Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Wash hands thoroughly after handling.
[Prevention]
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.
May cause polimerization.
Other hazards which do not
result in classification

---

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Tetrahydrofurfuryl Methacrylate (stabilized with MEHQ)
Percent: >95.0%(GC)
CAS Number: 2455-24-5
Synonyms: Methacrylic Acid Tetrahydrofurfuryl Ester
Chemical Formula: C9H14O3
MEHQ)

---

Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

---

Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Unsuitable extinguishing Solid streams of water
media:
Specific hazards arising This substance may polimerize explosively when heated or involved in a fire.
from the chemical: Container may explode when heated. Combat fire from a sheltered position.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

---

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into a
containment and cleaning covered container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.

---

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Wash hands and face thoroughly after
handling.
Use a ventilation, local exhaust if vapour or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Keep container tightly closed. Store in a cool and dark place.
Storage conditions:
Store away from incompatible materials such as oxidizing agents.
Light-sensitive
Packaging material: Comply with laws.

---

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Protective gloves.
Hand protection:
MEHQ)

---

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Colour: Colorless - Very pale yellow
Odour: No data available
pH: No data available
Melting point/freezing point:No data available
Boiling point/range: 85°C/0.5kPa
Flash point: 96°C
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: 1.04
Solubility(ies):
[Water] No data available
[Other solvents] No data available

---

Section 10. STABILITY AND REACTIVITY
Chemical stability: Polymerization may occur under the influences of heat, light or on contact with
polymelization initiators such as peroxides etc.
Possibility of hazardous No special reactivity has been reported.
reactions:
Conditions to avoid: Heat, Light
Incompatible materials: Oxidizing agents, Reducing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide
products:

---

Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

---

Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
Log Pow: No data available
No data available
Soil adsorption (Koc):
Henry's Law No data available
constant(PaM3/mol):
MEHQ)

---

Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

---

Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
Not listed
UN-No:

---

Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  甲基丙烯酸四氢糠基酯 在 lithium tetrafluoroborate 、 2,4,5,6-四(9H-咔唑-9-基)异酞腈 、 草酸 、 硫代水杨酸甲酯 作用下， 以 水 、 二甲基亚砜 、 乙腈 为溶剂， 反应 26.0h， 生成 (tetrahydrofuran-2-yl)methyl 2-methyl-4-oxo-9-phenylnonanoate
  参考文献：
  名称：

  使用两亲性自由基关键的双向延伸策略通过顺序光催化模块化获取 1,4-二羰基

  摘要：

  可以通过顺序形成 C-C 键连接到多个基材的有机分子可以用作多组分工艺中的关键。虽然它们可用于快速增加分子复杂性，但大多数报道的关键偶联方法依赖于使用有机金属物质作为强碳亲核试剂来形成 C-C 键，这缩小了官能团相容性。在这里，我们描述了一种无金属、自由基介导的偶联方法，在可见光光氧化还原条件下使用甲酰基稳定的鏻叶立德作为多功能关键。本方法利用鏻叶立德的两亲性特征，其既充当亲核又充当亲电碳中心自由基源。这些自由基中间体的逐步且可控的生成允许连续光催化，涉及两种机械上不同的自由基加成，这两种自由基加成均由具有高官能团耐受性的同一光催化剂在一锅中引发。该方法能够实现关键与两个电子差异的烯烃片段的双向组装，从而提供快速、模块化地获取 1,4-二羰基化合物作为通用合成中间体。

  DOI：

  10.1021/jacs.3c05337
• 作为产物：
  描述：

  四氢糠醇 在 氧气 作用下， 150.0 ℃ 、4.0 MPa 条件下， 以81.03%的产率得到甲基丙烯酸四氢糠基酯
  参考文献：
  名称：

  Ag-CeOx/MCM-41 催化四氢糠醇选择性氧化生成 2-甲基四氢呋喃

  摘要：

  四氢糠醇(THFA)是制备呋喃类化合物的重要原料。在此，我们首次采用无溶剂技术以THFA（THFA的开环和闭环）为原料成功合成了2-甲基四氢呋喃（2-MTHF）。采用浸渍法合成了Ag-CeO x /MCM-41催化剂。 N 2吸附-解吸、HR-TEM、XRD、XPS 和 Py-IR 对催化剂进行了表征。验证了Ag-CeO x /MCM-41 催化剂表面存在 Ce 4+ /Ce 3+氧化还原对和 Ag NP (Ag 0 )。 Ag和Ce在催化剂表面的协同作用、L酸的富集和少量B酸中心是THFA选择性氧化为2-MTHF的关键因素。实验结果表明，在150℃、4 MPa O 2压力、1 g催化剂的反应条件下，THFA转化率为100%，2-MTHF选择性为68.11%。我们的研究结果提供了一种从 THFA 制备 2-MTHF 的高效方法。

  DOI：

  10.1007/s11164-024-05239-z
• 作为试剂：
  描述：

  N-甲基-2-羟基乙胺 、 甲基丙烯酸缩水甘油酯 、 以 甲基丙烯酸四氢糠基酯 为溶剂， 反应 6.0h， 生成 2-Hydroxy-3-((2-hydroxyethyl)(methyl)amino)propyl methacrylate
  参考文献：
  名称：

  Epoxide (meth) acrylate composition

  摘要：

  本公开涉及一种组合物，其中至少包含一种自由基聚合单体M；至少一种自由基引发剂；至少一种环氧树脂A，其中每个分子平均含有多于一个环氧基团；以及至少一种式(I)的化合物。这样的组合物适用于粘合剂、密封剂或涂料。在应用后不久，它们具有很高的初始强度，并在室温下进一步硬化后达到高水平的最终强度。

  公开号：

  US08318870B2

文献信息

• [EN] A DENTAL COMPOSITION<br/>[FR] COMPOSITION DENTAIRE
  申请人：STICK TECH OY

  公开号：WO2020035321A1

  公开（公告）日：2020-02-20

  A dental composition comprising10-50 wt-% of a methacrylate-based first matrix component, a polymerisation system and as a second matrix component 1-50 wt-% of a compound having a general formula (I).

  一种牙科组合物，包括10-50重量％的甲基丙烯酸酯基第一基体组分，一个聚合体系，以及作为第二基体组分的具有一般式(I)的化合物，其含量为1-50重量％。
• [EN] LIGHT HARVESTING ARRAY<br/>[FR] RÉSEAU COLLECTEUR DE LUMIÈRE
  申请人：FLUROSOL IND PTY LTD

  公开号：WO2015024064A1

  公开（公告）日：2015-02-26

  The invention relates to a light harvesting array or dye comprising an acceptor linked to a donor, wherein at least one of the acceptor or the donor is an oligomeric unit comprising a first optionally substituted rylene linked via a linker group to a second optionally substituted rylene, the first optionally substituted rylene is linked to the acceptor or the donor and the second optionally substituted rylene is capable of energy transfer to at least one of the first optionally substituted rylene, the acceptor or the donor. The invention also relates to compounds which may be used as light harvesting arrays, methods for their manufacture, and devices and materials comprising the light harvesting array or dye, for example, chromophoric materials, light guides, photobioreactors, photoluminescent algae systems, photodetectors, photovoltaic devices and luminescent/fluorescent solar concentrators.

  该发明涉及一种光收集阵列或染料，包括一个与给体相连的受体，其中受体或给体中至少有一个是包含第一可选择取代的芳香烃单元通过连接基团连接到第二可选择取代的芳香烃的寡聚单元，第一可选择取代的芳香烃与受体或给体相连，第二可选择取代的芳香烃能够将能量传递至第一可选择取代的芳香烃、受体或给体中的至少一个。该发明还涉及可用作光收集阵列的化合物，其制造方法，以及包括光收集阵列或染料的设备和材料，例如，色素材料、光导管、光生物反应器、光致发光藻类系统、光探测器、光伏器件和发光/荧光太阳能聚光器。
• [EN] FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME<br/>[FR] POLYMERSOMES ET NANORÉACTEURS SENSIBLES À LA FORCE; PROCÉDÉS LES UTILISANT
  申请人：ADOLPHE MERKLE INSTITUTE UNIV OF FRIBOURG

  公开号：WO2019034597A1

  公开（公告）日：2019-02-21

  The mechanically induced melting properties of DNA were employed to achieve force labile membranes is described. Nucleobase pairs were used as mechanophores. Adenine and thymine functionalized complementary amphiphilic block copolymers were self-assembled into polymersomes. The nucleobases formed hydrogen bonds which were disrupted upon force stimulation. The exposure of the disconnected nucleobases to the hydrophobic matrix of the membranes lead to a change of permeability which permitted the exchange of water-soluble molecules throughout the polymer matrix. Moreover, the encapsulation of horseradish peroxidase enabled the reaction of luminol with hydrogen peroxide to yield a luminescence producing species similar to the marine bioluminescence. Moreover, the same nano-reactors were employed to catalyze the formation of a polyacrylamide gel when force was applied. Insights into the change of permeability of supramolecular networks upon force are provided. These systems are useful for drug delivery, as nanoreactors and for the selective release of curing agents for 3D printing, or fragrances.

  DNA的机械诱导熔化特性被用来实现易受力破裂的膜。核碱基对被用作机械感受器。腺嘌呤和胸腺嘧啶功能化的互补两性分块共聚物自组装成聚合体囊。核碱基形成氢键，在受力刺激下被破坏。断开的核碱基暴露在膜的疏水基质中，导致渗透性的改变，从而允许水溶性分子在聚合物基质中交换。此外，封装辣根过氧化物酶使得辣根酰胺与过氧化氢反应产生类似海洋生物发光的发光物种。此外，当施加力时，相同的纳米反应器被用来催化聚丙烯酰胺凝胶的形成。提供了关于受力下超分子网络渗透性变化的见解。这些系统可用于药物传递、纳米反应器以及用于3D打印的固化剂或香料的选择性释放。
• Dehydrogenative Silylation of Alkenes for the Synthesis of Substituted Allylsilanes by Photoredox, Hydrogen‐Atom Transfer, and Cobalt Catalysis
  作者：Wan‐Lei Yu、Yong‐Chun Luo、Lei Yan、Dan Liu、Zhu‐Yin Wang、Peng‐Fei Xu

  DOI：10.1002/anie.201904707

  日期：2019.8.5

  A synergistic catalytic method combining photoredox catalysis, hydrogen‐atom transfer, and proton‐reduction catalysis for the dehydrogenative silylation of alkenes was developed. With this approach, a highly concise route to substituted allylsilanes has been achieved under very mild reaction conditions without using oxidants. This transformation features good to excellent yields, operational simplicity

  开发了一种光催化氧化还原，氢原子转移和质子还原催化相结合的烯烃脱氢甲硅烷基化的协同催化方法。通过这种方法，在非常温和的反应条件下，无需使用氧化剂，即可获得高度简洁的取代烯丙基硅烷的制备方法。这种转变具有良好到极好的产量，操作简单和高原子经济性的特点。基于控制实验，提出了一种可能的反应机理。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。