N'-[9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-6-oxo-1H-purin-2-yl]-N,N-dibenzylmethanimidamide | 199003-62-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N'-[9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-6-oxo-1H-purin-2-yl]-N,N-dibenzylmethanimidamide
• CAS: 199003-62-8
• 化学式: C₃₂H₃₀N₆O₅
• 分子量: 578.627
• InChiKey: UUQFHTNVRFIZHG-MSIBFKAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N'-[9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-6-oxo-1H-purin-2-yl]-N,N-dibenzylmethanimidamide 在 4-二甲氨基吡啶 、 氨 、 三乙胺 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 甲醇 为溶剂， 生成 ((3aR,4R,6R,6aR)-6-(1-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-2-(((dibenzylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl tribenzyl benzyliminodiphosphate
  参考文献：
  名称：

  Synthesis of a functionalized GDP-analogue designed for anti-GDP antibody production

  摘要：

  An enzymatically stable analogue of GDP is prepared in 7 steps starting from guanosine. The guanine moiety is functionalized at the N-1 position so as to allow anchoring of the nucleotide onto a carrier protein for subsequent immunization of animals in order to raise antibodies against GDP. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00144-0
• 作为产物：
  描述：

  鸟苷 在 zinc(II) chloride 作用下， 生成 N'-[9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-6-oxo-1H-purin-2-yl]-N,N-dibenzylmethanimidamide
  参考文献：
  名称：

  Synthesis of a functionalized GDP-analogue designed for anti-GDP antibody production

  摘要：

  An enzymatically stable analogue of GDP is prepared in 7 steps starting from guanosine. The guanine moiety is functionalized at the N-1 position so as to allow anchoring of the nucleotide onto a carrier protein for subsequent immunization of animals in order to raise antibodies against GDP. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00144-0

文献信息

• Synthesis of a functionalized GDP-analogue designed for anti-GDP antibody production
  作者：Stéphane Vincent、Charles Mioskowski、Luc Lebeau

  DOI：10.1016/s0040-4039(98)00144-0

  日期：1998.4

  An enzymatically stable analogue of GDP is prepared in 7 steps starting from guanosine. The guanine moiety is functionalized at the N-1 position so as to allow anchoring of the nucleotide onto a carrier protein for subsequent immunization of animals in order to raise antibodies against GDP. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.