(Z)-5-methylhex-2-en-1-yl pivalate | 1280193-56-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-5-methylhex-2-en-1-yl pivalate
• 英文别名: [(Z)-5-methylhex-2-enyl] 2,2-dimethylpropanoate
• CAS: 1280193-56-7
• 化学式: C₁₂H₂₂O₂
• 分子量: 198.305
• InChiKey: JHQZIKUAHUEHEM-SREVYHEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  特戊酸氯甲酯 、 甲基三苯基溴化膦 、 异戊醛 在 苯基锂 、 lithium bromide 作用下， 以 四氢呋喃 、 二丁醚 为溶剂， 反应 0.92h， 以72%的产率得到(Z)-5-methylhex-2-en-1-yl pivalate
  参考文献：
  名称：

  Disubstituted Z-allylic esters by Wittig–Schlosser reaction using methylenetriphenylphosphorane

  摘要：

  由醛和亚甲基三苯基膦原位生成的β-锂氧磷鎓叶立德，可与卤甲基酯反应，以良好的产率和高度选择性地形成Z型二取代烯丙基酯。

  DOI：

  10.1039/c0cc04429f

文献信息

• [EN] CHIRAL CONTROL<br/>[FR] CONTRÔLE CHIRAL
  申请人：ONTORII INC

  公开号：WO2014012081A2

  公开（公告）日：2014-01-16

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2017062862A2

  公开（公告）日：2017-04-13

  Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.
• Disubstituted Z-allylic esters by Wittig–Schlosser reaction using methylenetriphenylphosphorane
  作者：David M. Hodgson、Tanzeel Arif

  DOI：10.1039/c0cc04429f

  日期：——

  β-Lithiooxyphosphonium ylides, generated in situ from aldehydes and methylenetriphenylphosphorane, react with halomethyl esters to form disubstituted allylic esters in good yields and with high Z-selectivity.

  由醛和亚甲基三苯基膦原位生成的β-锂氧磷鎓叶立德，可与卤甲基酯反应，以良好的产率和高度选择性地形成Z型二取代烯丙基酯。