Ethyl 1-(3-ethoxy-3-oxo-2-phenylpropyl)cyclopropane-1-carboxylate | 1312016-32-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 1-(3-ethoxy-3-oxo-2-phenylpropyl)cyclopropane-1-carboxylate
• 英文别名: ethyl 1-(3-ethoxy-3-oxo-2-phenylpropyl)cyclopropane-1-carboxylate
• CAS: 1312016-32-2
• 化学式: C₁₇H₂₂O₄
• 分子量: 290.359
• InChiKey: AENFYJCTMPTTLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 2-(2-hydroxyethyl)propenoate 在 1-氯-N,N,2-三甲基丙烯胺 、 sodium hydride 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 生成 Ethyl 1-(3-ethoxy-3-oxo-2-phenylpropyl)cyclopropane-1-carboxylate
  参考文献：
  名称：

  Ethyl-2-(2-chloroethyl)acrylate: a new very versatile α-cyclopropylester cation synthon. Efficient synthesis of cyclopropane ester derivatives by Michael addition-induced cyclization reaction

  摘要：

  We report here the use of the readily accessible ethyl-2-(2-chloroethyl)acrylate as a new very versatile alpha-cyclopropylester cation synthon, which reacts efficiently and selectively with carbon-, nitrogen-, sulfur- or phosphorus-centered nucleophiles through Michael addition followed by intramolecular capture of the incipient ester enolate to afford funtionalized cyclopropane esters in high yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.046

文献信息

• Ethyl-2-(2-chloroethyl)acrylate: a new very versatile α-cyclopropylester cation synthon. Efficient synthesis of cyclopropane ester derivatives by Michael addition-induced cyclization reaction
  作者：Mathilde Lachia、Sébastien Iriart、Myriam Baalouch、Alain De Mesmaeker、Renaud Beaudegnies

  DOI：10.1016/j.tetlet.2011.04.046

  日期：2011.6

  We report here the use of the readily accessible ethyl-2-(2-chloroethyl)acrylate as a new very versatile alpha-cyclopropylester cation synthon, which reacts efficiently and selectively with carbon-, nitrogen-, sulfur- or phosphorus-centered nucleophiles through Michael addition followed by intramolecular capture of the incipient ester enolate to afford funtionalized cyclopropane esters in high yields. (C) 2011 Elsevier Ltd. All rights reserved.