6-chloro-2-N-2-chloroethyl-3(2H)-pyridazinone | 122913-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-chloro-2-N-2-chloroethyl-3(2H)-pyridazinone
• 英文别名: 6-chloro-2-(2-chloro-ethyl)-2H-pyridazin-3-one；3-Chlor-1-(2-chlor-ethyl)-pyridazon-6；6-Chloro-2-(2-chloroethyl)pyridazin-3-one
• CAS: 122913-87-5
• 化学式: C₆H₆Cl₂N₂O
• 分子量: 193.032
• InChiKey: VNJVDPGYPJUPIR-UHFFFAOYSA-N

物化性质

• 沸点：
  280.6±42.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-chloro-2-N-2-chloroethyl-3(2H)-pyridazinone 、 2-苯氧基乙胺 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 6-Chloro-2-[2-(2-phenoxyethylamino)ethyl]pyridazin-3-one
  参考文献：
  名称：

  Synthesis, antihypertensive and α-adrenoceptor activity of novel 2-aminoalkyl-3(2H)-pyridazinones

  摘要：

  A number of 2-phenoxyalkylaminoalkyl- and 2-[1,4]benzodioxanylmethylaminoalkyl-3(2H)-pyridazinones were synthesized and tested for hypotensive and antihypertensive activity as well as for alpha-1- and alpha-2-adrenoceptor binding affinities. Some derivatives, eg 5.5, 5.9, 5.12, 6.4 and 6.10, showed strong hypotensive/antihypertensive effect and high affinity for alpha-2- and alpha-1-adrenoceptors. Compound 5.5 was selected for clinical study. In its mode of action a potassium channel opening activity may also be involved.

  DOI：

  10.1016/0223-5234(92)90098-l
• 作为产物：
  描述：

  3-Chlor-6-(2-hydroxy-ethoxy)-pyridazin 、 氯化亚砜 生成 6-chloro-2-N-2-chloroethyl-3(2H)-pyridazinone
  参考文献：
  名称：

  MATYUS, PETER;MAKK, NANDOR;KASZTREINER, ENDRE;JERKOVICH, GYULE, HETEROCYCLES, 29,(1989) N, C. 67-77

  摘要：

  DOI：

文献信息

• IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES
  申请人：Berdini Valerio

  公开号：US20120208791A1

  公开（公告）日：2012-08-16

  The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

  本发明涉及新的双环杂环衍生物化合物，涉及包含该化合物的药物组合物以及涉及使用该化合物治疗疾病，例如癌症的用途。
• MATYUS, PETER;MAKK, NANDOR;KASZTREINER, ENDRE;JERKOVICH, GYULE, HETEROCYCLES, 29,(1989) N, C. 67-77
  作者：MATYUS, PETER、MAKK, NANDOR、KASZTREINER, ENDRE、JERKOVICH, GYULE

  DOI：——

  日期：——
• US8796244B2
  申请人：——

  公开号：US8796244B2

  公开（公告）日：2014-08-05
• Synthesis, antihypertensive and α-adrenoceptor activity of novel 2-aminoalkyl-3(2H)-pyridazinones
  作者：P Mátyus、J Kosáry、E Kasztreiner、N Makk、E Diesler、K Czakó、G Rabloczky、L Jaszlits、E Horváth、Z Tömösközi、G Cseh、E Horváth、P Arányi

  DOI：10.1016/0223-5234(92)90098-l

  日期：1992.3

  A number of 2-phenoxyalkylaminoalkyl- and 2-[1,4]benzodioxanylmethylaminoalkyl-3(2H)-pyridazinones were synthesized and tested for hypotensive and antihypertensive activity as well as for alpha-1- and alpha-2-adrenoceptor binding affinities. Some derivatives, eg 5.5, 5.9, 5.12, 6.4 and 6.10, showed strong hypotensive/antihypertensive effect and high affinity for alpha-2- and alpha-1-adrenoceptors. Compound 5.5 was selected for clinical study. In its mode of action a potassium channel opening activity may also be involved.