2-[[7-[(2-anilino-2-oxoethyl)amino]-2-butyl-1,3-dioxobenzo[de]isoquinolin-6-yl]amino]-N-phenylacetamide | 1313865-94-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[7-[(2-anilino-2-oxoethyl)amino]-2-butyl-1,3-dioxobenzo[de]isoquinolin-6-yl]amino]-N-phenylacetamide
• CAS: 1313865-94-9
• 化学式: C₃₂H₃₁N₅O₄
• 分子量: 549.629
• InChiKey: PXVIGPXDZFXEPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.34
• 重原子数：
  41.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  119.64
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2-溴-N-苯乙酰胺 在 sodium azide 、 3.5% Pd/C 、 氢气 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 甲乙醚 、 二甲基亚砜 为溶剂， 反应 3.0h， 生成 2-[[7-[(2-anilino-2-oxoethyl)amino]-2-butyl-1,3-dioxobenzo[de]isoquinolin-6-yl]amino]-N-phenylacetamide
  参考文献：
  名称：

  A ratiometric and exclusively selective CuII fluorescent probe based on internal charge transfer (ICT)

  摘要：

  A new ratiometric and exclusively selective fluorescent probe N-butyl-4,5-di[N-(phenyl)-2-(amino)-acetamino]-1,8-naphthalimide (1) was designed and synthesized on the basis of the mechanism of internal charge transfer (ICT). The probe 1 showed exclusively selectivity for Cull in the presence of a variety of other metal ions in aqueous ethanol solutions and the binding mode of probe 1 with Cu-II was 1:1 metal-ligand complex. Fluorescent emission spectra of probe 1 in the presence of Cu-II showed a 50 nm blue shift, which is from 521 nm to 471 nm. Furthermore, probe 1 shows the same fluorescent change with the Cu-II in living cells. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.001

文献信息

• A ratiometric and exclusively selective CuII fluorescent probe based on internal charge transfer (ICT)
  作者：Xiufu Chen、Jingyun Wang、Jingnan Cui、Zhaochao Xu、Xiaojun Peng

  DOI：10.1016/j.tet.2011.05.001

  日期：2011.7

  A new ratiometric and exclusively selective fluorescent probe N-butyl-4,5-di[N-(phenyl)-2-(amino)-acetamino]-1,8-naphthalimide (1) was designed and synthesized on the basis of the mechanism of internal charge transfer (ICT). The probe 1 showed exclusively selectivity for Cull in the presence of a variety of other metal ions in aqueous ethanol solutions and the binding mode of probe 1 with Cu-II was 1:1 metal-ligand complex. Fluorescent emission spectra of probe 1 in the presence of Cu-II showed a 50 nm blue shift, which is from 521 nm to 471 nm. Furthermore, probe 1 shows the same fluorescent change with the Cu-II in living cells. (C) 2011 Elsevier Ltd. All rights reserved.