5-(5-bromopyridin-3-yl)-1,3,4-thiadiazol-2-amine | 70057-75-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(5-bromopyridin-3-yl)-1,3,4-thiadiazol-2-amine
• CAS: 70057-75-9
• 化学式: C₇H₅BrN₄S
• 分子量: 257.113
• InChiKey: WBMPOMGBOZKUTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(5-bromopyridin-3-yl)-1,3,4-thiadiazol-2-amine 在 N,N-二异丙基乙胺 、 三氯氧磷 作用下， 以 乙腈 为溶剂， 反应 2.2h， 生成 tert-butyl 4-(2-(5-bromopyridin-3-yl)-7-oxo-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-yl)piperazine-1-carboxylate
  参考文献：
  名称：

  A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor

  摘要：

  A collection of alpha IIb beta 3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure- activity relationships, binding modality, and pharmacokinetic and pharmacodynamic profiles highlight the potential of these small molecule ion displacement ligands as attractive candidates for clinical development. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2013.12.122
• 作为产物：
  描述：

  2-(5-bromonicotinoyl)hydrazinecarbothioamide 在 polyphosphoric acid 作用下， 反应 4.5h， 以80%的产率得到5-(5-bromopyridin-3-yl)-1,3,4-thiadiazol-2-amine
  参考文献：
  名称：

  A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor

  摘要：

  A collection of alpha IIb beta 3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure- activity relationships, binding modality, and pharmacokinetic and pharmacodynamic profiles highlight the potential of these small molecule ion displacement ligands as attractive candidates for clinical development. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2013.12.122

文献信息

• A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor
  作者：Jian-kang Jiang、Joshua G. McCoy、Min Shen、Christopher A. LeClair、Wenwei Huang、Ana Negri、Jihong Li、Robert Blue、Amanda Weil Harrington、Sarasija Naini、George David、Won-Seok Choi、Elisabetta Volpi、Joseph Fernandez、Mariana Babayeva、Mark A. Nedelman、Marta Filizola、Barry S. Coller、Craig J. Thomas

  DOI：10.1016/j.bmcl.2013.12.122

  日期：2014.2

  A collection of alpha IIb beta 3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure- activity relationships, binding modality, and pharmacokinetic and pharmacodynamic profiles highlight the potential of these small molecule ion displacement ligands as attractive candidates for clinical development. Published by Elsevier Ltd.