1-oxo-1,2,3,4-tetrahydrophenanthrene oxime | 781-40-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1-oxo-1,2,3,4-tetrahydrophenanthrene oxime
• 英文别名: 3,4-dihydro-2H-phenanthren-1-one oxime；3,4-Dihydro-2H-phenanthren-1-on-oxim；3,4-dihydro-2H-phenanthren-1-one-oxime；1-Hydroxyimino-1,2,3,4-tetrahydro-phenanthren；1-Oximino-1,2,3,4-tetrahydrophenanthren；1,2,3,4-Tetrahydrophenanthren-1-one oxime；N-(3,4-dihydro-2H-phenanthren-1-ylidene)hydroxylamine
• CAS: 781-40-8
• 化学式: C₁₄H₁₃NO
• 分子量: 211.263
• InChiKey: ZKLJNIPOWCPKDZ-UHFFFAOYSA-N

物化性质

• 熔点：
  166 °C
• 沸点：
  422.5±15.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-oxo-1,2,3,4-tetrahydrophenanthrene oxime 在 盐酸 、 sodium amalgam 、 乙醇 、 溶剂黄146 、 铂 作用下， 生成 1-氨基菲
  参考文献：
  名称：

  A New Synthesis of 1-Aminophenanthrene

  摘要：

  DOI：

  10.1021/ja01281a501
• 作为产物：
  描述：

  3,4-二氢-2H-菲-1-酮 生成 1-oxo-1,2,3,4-tetrahydrophenanthrene oxime
  参考文献：
  名称：

  Mittlere ringe-XIII：死于分子内的acylierung derω-（1-萘基）-fettsäuren

  摘要：

  ω-芳基链烷酸的分子内Friedel-Crafts环化是苯系列中具有中型和大环的双环酮的有价值的合成途径，已用ω-（1-萘基）链烷酰氯进行了研究。包括萘基-己酸的低级成员在位置2处闭合环以形成IV。较高的同源酸显示优先选择7位的壬基化，从而提供了一种新型的异核萘环酮（VII）。在ω-（1-萘基）癸酸环化过程中，1,4环的闭合与1,7类型竞争。

  DOI：

  10.1016/0040-4020(58)88047-3

文献信息

• Lipoxygenase inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：US05140047A1

  公开（公告）日：1992-08-18

  Tricyclic hydroxyurea and hydroxamate compounds, pharmaceutical compositions, and their use as as inhibitors of the oxidation of polyunsaturated fatty acids, such as by inhibition on the 5-lipoxygenase enzyme, and treatment of diseases therein.

  三环羟基脲和羟酸酯化合物，制药组合物及其用作抑制多不饱和脂肪酸氧化的抑制剂，例如通过抑制5-脂氧酶酶的作用，并用于治疗相关疾病。
• N-substituted naphthofused lactams
  申请人：Novo Nordisk A/S

  公开号：US05817654A1

  公开（公告）日：1998-10-06

  The present invention relates to novel N-substituted naphthofused lactams and salts thereof of the formula ##STR1## Compounds of the general formula I possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds may be used in the treatment of conditions which require stimulation of growth hormone production or secretion such as in humans with growth hormone deficiency or where increased growth hormone plasma levels are desired, for instance in elderly patients or in livestock.

  本发明涉及新型N-取代萘并内酰胺及其盐的化合物，其化学式为##STR1## 具有通式I的化合物具有刺激内源性生长激素释放的能力。因此，这些化合物可用于治疗需要刺激生长激素产生或分泌的情况，例如具有生长激素缺乏症的人类，或者需要增加生长激素血浆水平的情况，例如老年患者或家畜。
• Studies in the Phenanthrene Series. XII.¹ Amino Alcohols Derived from 1,2,3,4-Tetrahydrophenanthrene²
  作者：Alfred Burger、Erich Mosettig

  DOI：10.1021/ja01300a017

  日期：1936.9
• Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase:  Pharmacodynamic, Pharmacokinetic, and <i>in Vitro</i> Metabolic Studies Characterizing <i>N</i>-Hydroxy-<i>N</i>-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea
  作者：Jerry L. Adams、Ravi S. Garigipati、Margaret Sorenson、Stanley J. Schmidt、William R. Brian、John F. Newton、Kathy A. Tyrrell、Eric Garver、Lee A. Yodis、Marie Chabot-Fletcher、Maritsa Tzimas、Edward F. Webb、John J. Breton、Don E. Griswold

  DOI：10.1021/jm960271d

  日期：1996.1.1

  A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB(4) biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in the mouse of selected compounds was assessed using an ex vivo LTB(4) assay and an adoptive peritoneal anaphylaxis assay at extended pretreat times. Compounds with an extended duration of action were reexamined as the individual enantiomers in the ex vivo assay, and the (S) enantiomer of N-hydroxy-N-[2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl]urea, (+)-1a (SE 202235), was selected as the compound with the best overall profile. Higher plasma concentrations and longer plasma half-lives were found for (+)-1a relative to its enantiomer in the mouse, monkey, and dog. In vitro metabolic studies in mouse liver microsomes established enantiospecific glucuronidation as a likely mechanism for the observed differences between the enantiomers of la. Enantioselective glucuronidation favoring (-)-1a was also found in human liver microsomes.
• Langenbeck; Weissenborn, Chemische Berichte, 1939, vol. 72, p. 724,727
  作者：Langenbeck、Weissenborn

  DOI：——

  日期：——