Tenivastatin calcium | 151006-18-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Tenivastatin calcium
• 英文别名: calcium;(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• CAS: 151006-18-7
• 化学式: C50H78CaO12
• 分子量: 911.2
• InChiKey: FGHWDPOUOIKHKK-XQOMDNQHSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  5.16
• 重原子数：
  63
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  214
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• Delayed-release oral formulation of dihydroxy open acid simvastatin and salts and esters thereof
  申请人：MERCK & CO. INC.

  公开号：EP1036563A1

  公开（公告）日：2000-09-20

  The instant invention provides orally administrable pharmaceutical compositions suitable for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising a therapeutically effective amount of a statin selected from dihydroxy open acid simvastatin and a pharmaceutically acceptable salt or ester thereof in a delayed-release dosage form wherein substantial release of the compound from the dosage form is delayed until after passage of the dosage form through the stomach.

  本发明提供了可口服的药物组合物，适用于抑制 HMG-CoA 还原酶以及治疗和/或降低受 HMG-CoA 还原酶抑制影响的疾病和病症的风险，该组合物包含治疗有效量的他汀类药物，该他汀类药物选自二羟基开酸辛伐他汀及其药学上可接受的盐或酯，采用缓释剂型，其中化合物从剂型中的实质性释放被延迟到剂型通过胃之后。
• Crystalline hydrated dihydroxy open-acid simvastatin calcium salt
  申请人：MERCK & CO. INC.

  公开号：EP1036783B1

  公开（公告）日：2003-05-21