Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies
作者:Shehryar Hameed、Kanwal、Faiza Seraj、Rafaila Rafique、Sridevi Chigurupati、Abdul Wadood、Ashfaq Ur Rehman、Vijayan Venugopal、Uzma Salar、Muhammad Taha、Khalid Mohammed Khan
DOI:10.1016/j.ejmech.2019.111677
日期:2019.12
Benzotriazoles (4-6) were synthesized which were further reacted with different substituted benzoic acids and phenacylbromides to synthesize benzotriazole derivatives (7-40). The synthetic compounds (7-40) were characterized via different spectroscopic techniques including EI-MS, HREI-MS, 1H-, and 13C NMR. These molecules were examined for their anti-hyperglycemic potential hence were evaluated for
The influence of alkoxy chain length on the ferroelectric properties of chiral fluorenol liquid crystals
作者:Jeffrey C. Roberts、Zachary M. Hudson、Robert P. Lemieux
DOI:10.1039/b804673e
日期:——
A series of isomeric chiral fluorenol mesogens with different alkoxy chain length combinations have been prepared in order to test a model for the origin of polar order in the chiral SmC* phase formed by these compounds. The results show that the transposition of alkoxy side chains has no effect on the sign of spontaneous polarization, PS, which is inconsistent with a model suggesting that polar order arises from a rotational bias of antiparallel hydrogen-bonded dimers that minimizes free volume in the tilted SmC* phase.