2,3-Dibromo-3-(2-fluorophenyl)-1-phenylpropan-1-one | 140861-32-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2,3-Dibromo-3-(2-fluorophenyl)-1-phenylpropan-1-one
• CAS: 140861-32-1
• 化学式: C₁₅H₁₁Br₂FO
• 分子量: 386.058
• InChiKey: OCXWIRZCHULCRG-UHFFFAOYSA-N

物化性质

• 沸点：
  408.3±45.0 °C(Predicted)
• 密度：
  1.679±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(4-hydrazinocarbonyl-5-methyl-1H-1,2,3-triazol-1-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 、 2,3-Dibromo-3-(2-fluorophenyl)-1-phenylpropan-1-one 以 吡啶 为溶剂， 以80%的产率得到6-{4-[5-(2-fluorophenyl)-3-phenyl-1H-pyrazol-1-ylcarbonyl]-5-methyl-1H-1,2,3-triazol-1-yl}-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  Synthesis and antiviral evaluation of 1,3-dimethyl-6-(1H-1,2,3-triazol-1-YL)pyrimidine-2,4(1H,3H)-dione derivatives

  摘要：

  Some 6-(1H-1,2,3-triazol-1-yl) pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.

  DOI：

  10.1007/s10593-010-0633-8
• 作为产物：
  描述：

  o-Fluorobenzylideneacetophenone 在 溴 作用下， 以 溶剂黄146 为溶剂， 以51%的产率得到2,3-Dibromo-3-(2-fluorophenyl)-1-phenylpropan-1-one
  参考文献：
  名称：

  Aziridinyl ketones and their cyclic anils. 11. Fluorine-containing photochromes

  摘要：

  DOI：

  10.1007/bf00484355

文献信息

• Aziridinyl ketones and their cyclic anils. 10. 2,4,6-Triaryl-1,3-diazabicyclo[3.1.0]hex-3-enes
  作者：V. D. Orlov、Z. Kaluski、�. Figas、N. P. Vorob'eva、A. I. Bakumenko、F. G. Yaremenko

  DOI：10.1007/bf00472284

  日期：1991.8
• Aziridinyl ketones and their cyclic anils. 11. Fluorine-containing photochromes
  作者：V. D. Orlov、N. P. Vorob'eva、A. A. Tishchenko、O. M. Pikalev、V. I. Popov、L. M. Yagupol'skii

  DOI：10.1007/bf00484355

  日期：1991.9
• Synthesis and antiviral evaluation of 1,3-dimethyl-6-(1H-1,2,3-triazol-1-YL)pyrimidine-2,4(1H,3H)-dione derivatives
  作者：A. Sh. El-Etrawy、A. A.-H. Abdel-Rahman

  DOI：10.1007/s10593-010-0633-8

  日期：2010.12

  Some 6-(1H-1,2,3-triazol-1-yl) pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.