[4-chloro-1-(4-chlorophenyl)-1H-imidazol-5-yl]-methanol | 1333713-32-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [4-chloro-1-(4-chlorophenyl)-1H-imidazol-5-yl]-methanol
• 英文别名: [5-chloro-3-(4-chlorophenyl)imidazol-4-yl]methanol
• CAS: 1333713-32-8
• 化学式: C₁₀H₈Cl₂N₂O
• 分子量: 243.092
• InChiKey: ACKMKIYMQAYHOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [4-chloro-1-(4-chlorophenyl)-1H-imidazol-5-yl]-methanol 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以76%的产率得到4-chloro-5-chloromethyl-1-(4-chlorophenyl)-1H-imidazole
  参考文献：
  名称：

  Polyfunctional imidazoles: VII. 1-aryl-4-chloro-5-[hydroxy(halo)methyl]-1H-imidazoles and their derivatives

  摘要：

  The reduction of 1-aryl-4-chloro-1H-imidazole-5-carbaldehydes with sodium tetrahydridoborate gave 1-aryl-4-chloro-1H-imidazol-5-ylmethanols which were converted into 5-chloromethyl and 5-fluoromethyl derivatives. 1-Aryl-4-chloro-5-chloromethyl-1H-imidazoles reacted with sodium azide, secondary amines, thiols, and triphenylphosphine to produce the corresponding products of chlorine replacement in the 5-chloromethyl group.

  DOI：

  10.1134/s1070428013040131
• 作为产物：
  描述：

  4-chloro-1-(4-chlorophenyl)-1H-imidazole-5-carbaldehyde 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以82%的产率得到[4-chloro-1-(4-chlorophenyl)-1H-imidazol-5-yl]-methanol
  参考文献：
  名称：

  Polyfunctional imidazoles: VII. 1-aryl-4-chloro-5-[hydroxy(halo)methyl]-1H-imidazoles and their derivatives

  摘要：

  The reduction of 1-aryl-4-chloro-1H-imidazole-5-carbaldehydes with sodium tetrahydridoborate gave 1-aryl-4-chloro-1H-imidazol-5-ylmethanols which were converted into 5-chloromethyl and 5-fluoromethyl derivatives. 1-Aryl-4-chloro-5-chloromethyl-1H-imidazoles reacted with sodium azide, secondary amines, thiols, and triphenylphosphine to produce the corresponding products of chlorine replacement in the 5-chloromethyl group.

  DOI：

  10.1134/s1070428013040131

文献信息

• Polyfunctional imidazoles: VII. 1-aryl-4-chloro-5-[hydroxy(halo)methyl]-1H-imidazoles and their derivatives
  作者：V. A. Chornous、A. N. Grozav、D. V. Klyukovskii、A. V. Bezdudnyi、M. V. Vovk

  DOI：10.1134/s1070428013040131

  日期：2013.4

  The reduction of 1-aryl-4-chloro-1H-imidazole-5-carbaldehydes with sodium tetrahydridoborate gave 1-aryl-4-chloro-1H-imidazol-5-ylmethanols which were converted into 5-chloromethyl and 5-fluoromethyl derivatives. 1-Aryl-4-chloro-5-chloromethyl-1H-imidazoles reacted with sodium azide, secondary amines, thiols, and triphenylphosphine to produce the corresponding products of chlorine replacement in the 5-chloromethyl group.