(S)-5-methylhexan-3-ol | 93031-24-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-5-methylhexan-3-ol
• 英文别名: (S)-5-methyl-3-hexanol；(3S)-5-methylhexan-3-ol
• CAS: 93031-24-4
• 化学式: C₇H₁₆O
• 分子量: 116.203
• InChiKey: RGCZULIFYUPTAR-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异戊醛 生成 (S)-5-methylhexan-3-ol
  参考文献：
  名称：

  SOGO, KEHNDZO

  摘要：

  DOI：

文献信息

• New Chiral Ligands Derived from (S)-Leucine for the Enantioselective Addition of Diethylzinc to Aldehydes
  作者：Yasuhiro Kawanami、Tomoko Mitsuie、Misuzu Miki、Takanobu Sakamoto、Kazumi Nishitani

  DOI：10.1016/s0040-4020(99)00971-0

  日期：2000.1

  A new series of chiral β-amino alcohols derived from (S)-leucine has been synthesized. The amino alcohol possessing a piperidine ring and a phenethyl group on the carbinol carbon atom was found to be an efficient ligand to catalyze the enantioselective addition of diethylzinc to aromatic (up to 97% ee) and aliphatic (up to 95% ee) aldehydes.

  合成了一系列新的衍生自（S）-亮氨酸的手性β-氨基醇。发现在甲醇碳原子上具有哌啶环和苯乙基的氨基醇是催化二乙基锌与芳族（至多97％ee）和脂肪族（至多95％ee）醛的对映选择性加成的有效配体。
• Synthesis of Chiral Amino Alcohols Embodying the Bispidine Framework and Their Application as Ligands in Enantioselectively Catalyzed Additions to CO and CC Groups
  作者：Jan Spieler、Oliver Huttenloch、Herbert Waldmann

  DOI：10.1002/(sici)1099-0690(200002)2000:3<391::aid-ejoc391>3.0.co;2-r

  日期：2000.2

  course of enantioselective transformations, bispidine amino alcohols built up by these two routes were investigated as chiral ligands in the enantioselectively catalyzed addition of diethylzinc to aldehydes and chalcone. In general, tridentate ligands containing one chiral amino alcohol fragment and a second amino substituent without a stereogenic center were more efficient than tetradentate ligands with

  已经开发了两种普遍适用的合成包含双吡啶骨架的手性氨基醇的路线。在线性路线 A 中，双吡啶骨架是由手性伯胺通过中间体形成哌啶酮和双吡啶酮依次构建的。在收敛路线 B ​​中，首先形成非手性双吡啶，然后通过氮碱与手性亲电试剂的反应引入 N-取代基。为了确定双吡啶核心及其 N 取代基是否能影响对映选择性转化的空间过程，研究了通过这两种途径构建的双吡啶氨基醇作为手性配体在二乙基锌对醛和查耳酮的对映选择性催化加成中。一般来说，含有一个手性氨基醇片段和没有立体中心的第二个氨基取代基的三齿配体比具有两个氨基醇结构单元的四齿配体更有效。使用最好的配体，二乙基锌对芳香族和脂肪族醛的对映选择性加成以 83-98% ee 进行，二乙基锌向查耳酮的镍催化加成达到 85% ee。
• Aziridino alcohols as catalysts for the enantioselective addition of diethylzinc to aldehydes
  作者：David Tanner、Hanne T. Kornø、David Guijarro、Pher G. Andersson

  DOI：10.1016/s0040-4020(98)00875-8

  日期：1998.11

  The chiral aziridino alcohols 1 – 3 have been prepared either from amino acids (1a from serine; 1b – 1i and 3 from threonine; 2a – 2e from allo-threonine) or via asymmetric synthesis (1j, 1k, 1l and 2f from methyl cinnamate). These easily available ligands act as catalysts for the enantioselective addition of diethylzinc to benzaldehyde, with up to 90% stereoselectivity. The absolute configuration

  手性氮丙啶基醇1 - 3已经从氨基酸制备或者（1A从丝氨酸; 1B - 1I和3从苏氨酸;图2a -图2e从同种异体-苏氨酸），或通过不对称合成（1J，1K，1L和2F从肉桂酸甲酯）。这些容易获得的配体充当二乙基锌向苯甲醛对映选择性加成的催化剂，立体选择性高达90％。醇产物的绝对构型取决于氮丙啶环的取代模式，并提出了不同的过渡态模型来解释所观察到的对映选择性的转换。C 2酒石酸制备了对称的叠氮基叠氮二醇4a – 4h，并且还以较高的化学产率催化有机锌加成反应，并且高达94％的具有醚侧链的ee C 2对称配体5a – 5c效率较低（最高为46％ee）。除醛9-11外，还测试了最有效的配体（4c），ee最高为97％。
• Catalytic enantioselective reaction. Part 9. 1,2-O-Isopropylidene-5-deoxy-5-N,N-dialkyl (or -N-monoalkyl)amino-α-<scp>D</scp>-xylofuranose derivatives as highly effective chiral catalysts for enantioselective addition of diethylzinc to aliphatic and aromatic aldehydes
  作者：Byung Tae Cho、Namdu Kim

  DOI：10.1039/p19960002901

  日期：——

  (or-N-monoalkyl)amino-α-D-xylofuranose derivatives have been prepared form D-xylose and their enantioselectivities as chiral catalysts for the addition of diethylzinc to aldehydes have been examined. Or the chiral catalysts examined, 5-deoxy-1,2-O-isopropylidene-5-morpholino-α-D-xylofuranose provides high enantioselectivity for aromatic and relatively hindered aliphatic aldehydes, and 5-deoxy-5-hexaydroazepinyl-1

  一系列新的1,2- ö异亚丙基-5-脱氧-5- Ñ，Ñ二烷基（或- Ñ -monoalkyl）氨基α- d -xylofuranose衍生物已被制备的形式d木糖以及它们的对映选择性手性已经研究了用于将二乙基锌加成到醛中的催化剂。或所研究的手性催化剂5-脱氧-1,2- O-异亚丙基-5-吗啉代-α- D-木呋喃糖为芳香族和相对受阻的脂族醛和5-脱氧-5-六氮杂pin啶基-1,2提供了高对映选择性- ö异亚丙基α- d -xylofuranose为受阻的脂族醛高度有效的。
• Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels
  申请人：Kyle Donald J.

  公开号：US20130296281A1

  公开（公告）日：2013-11-07

  The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R 1 , and Z 1 -Z 5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及具有式（I）的芳基和杂芳基取代化合物，以及其药学上可接受的盐、前药或溶剂化物，其中G、R1和Z1-Z5如规范中所述。本发明还涉及利用式（I）的化合物治疗对钠通道阻滞有响应的疾病。本发明的化合物特别适用于治疗疼痛。