N-Carbobenzyloxyisoglutamine Ethyl Ester | 6398-09-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Carbobenzyloxyisoglutamine Ethyl Ester
• 英文别名: Benzyloxycarbonyl-L-glutaminsaeure-α-amid-γ-ethylester；Cbz-isoglutamine ethyl ester；ethyl (4S)-5-amino-5-oxo-4-(phenylmethoxycarbonylamino)pentanoate
• CAS: 6398-09-0
• 化学式: C₁₅H₂₀N₂O₅
• 分子量: 308.334
• InChiKey: KCAFSTQPHYYMBD-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  水 、 N-Carbobenzyloxyisoglutamine Ethyl Ester 、 乙腈 在 吡啶 、 溶剂黄146 、 三氟乙酸酐 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 以11.90 g (82%)的产率得到N-Carbobenzyloxy-γ-cyano-γ-aminobutyric Acid Ethyl Ester
  参考文献：
  名称：

  Metal radionuclide labeled proteins for diagnosis and therapy

  摘要：

  蛋白质共轭螯合金属放射性同位素用于体内使用。提供了用于高效制备多肽组合物的中间体。

  公开号：

  US04897255A1
• 作为产物：
  描述：

  L-焦谷氨酰胺 在 盐酸 作用下， 生成 N-Carbobenzyloxyisoglutamine Ethyl Ester
  参考文献：
  名称：

  Rolski,S.; Sabiniewicz,S., Roczniki Chemii, 1966, vol. 40, p. 689 - 694

  摘要：

  DOI：

文献信息

• Method of radiolabeling chelating compounds comprising sulfur atoms with
  申请人：NeoRx Corporation

  公开号：US05021556A1

  公开（公告）日：1991-06-04

  Chelating compounds which comprise one or more sulfur atoms and are to be radiolabeled with metal radionuclides to form the corresponding chelates are disclosed. The chelating compounds comprise thioacetal or hemithioacetal sulfur protecting groups which are displaced during the radiolabeling reaction, which is conducted at acidic pH, such that bonds form between said sulfur atoms and said radionuclide. The resulting metal radionuclide chelates have diagnostic and therapeutic medical uses.

  本发明揭示了包含一个或多个硫原子并且将与金属放射性核素进行放射标记以形成相应螯合物的螯合化合物。这些螯合化合物包括硫缩醛或半硫缩醛硫保护基，这些基团在放射标记反应中被取代，该反应在酸性pH下进行，使得所述硫原子与所述放射性核素之间形成键。由此产生的金属放射性核素螯合物具有诊断和治疗医学用途。
• Metal radionuclide chelating compounds for improved chelation kinetics
  申请人：NeoRx Corporation

  公开号：US05075099A1

  公开（公告）日：1991-12-24

  The present invention provides metal chelating compounds, to chelates and chelate-targeting agent conjugates formed from the chelating compounds, and to methods for making and using these compositions. The chelating compounds incorporate two nitrogen atoms and three sulfur atoms ("N.sub.2 S.sub.3 "), two nitrogen atoms and four sulfur atoms ("N.sub.2 S.sub.4 "), or three nitrogen atoms and three sulfur atoms ("N.sub.3 S.sub.3 "). Metals, and metal oxides, capable of being chelated by the compounds include those that are radionuclides, such as .sup.99m Tc and .sup.186/188 Re. The targeting agent portion of the chelate-targeting agent conjugates provided includes antibodies, peptides, hormones, enzymes and biological response modifiers. Methods for making the conjugates are provided and encompass the addition of a metal, or metal oxide, to a chelating compound prior to attachment to a targeting agent as well as subsequent to the attachment. Another aspect of the invention provides kits for producing chelate-targeting agent conjugates for radiopharmaceutical use. An additional aspect of the invention provides methods for using the chelate-targeting agent conjugates for diagnostic and therapeutic purposes, such as detection of a target site and delivery of a radionuclide to the site, respectively.

  本发明提供了金属螯合化合物，用于形成螯合物和螯合靶向剂偶联物的螯合化合物，以及制备和使用这些组合物的方法。这些螯合化合物包含两个氮原子和三个硫原子（“N.sub.2S.sub.3”），两个氮原子和四个硫原子（“N.sub.2S.sub.4”）或三个氮原子和三个硫原子（“N.sub.3S.sub.3”）。可被这些化合物螯合的金属和金属氧化物包括放射性核素，例如.sup.99m Tc和.sup.186/188 Re。螯合靶向剂偶联物的靶向剂部分包括抗体、肽、激素、酶和生物反应修饰剂。本发明提供了制备偶联物的方法，包括在连接到靶向剂之前或之后向螯合化合物中添加金属或金属氧化物。本发明的另一个方面提供了用于制备放射性药物的螯合靶向剂偶联物的试剂盒。本发明的另一个方面提供了将螯合靶向剂偶联物用于诊断和治疗目的的方法，例如检测靶位点和将放射性核素输送到该位点。
• Protein conjugate containing metal radionuclide labeled proteins
  申请人：NeoRx Corporation

  公开号：US05756685A1

  公开（公告）日：1998-05-26

  Protein, ligand and anti-ligand conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the compositions efficiently.

  提供了蛋白质、配体和抗配体共轭螯合金属放射性核素，用于体内使用。提供了制备这些组合物的中间体，以有效地制备这些组合物。
• Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
  申请人：NEORX CORPORATION

  公开号：EP0300431A2

  公开（公告）日：1989-01-25

  Chelating compounds which comprise one or more sulfur atoms and are to be radiolabeled with metal radionuclides to form the corresponding chelates are disclosed. The chelating compounds comprise thioacetal or hemithioacetal sulfur pro­tecting groups which are displaced during the radiolabeling reaction, which is conducted at acidic pH, such that bonds form between said sulfur atoms and said radionuclide. The resulting metal radionuclide chelates have diagnostic and therapeutic medical uses.

  本发明公开了包含一个或多个硫原子的螯合化合物，这些化合物将用金属放射性核素进行放射性标记以形成相应的螯合物。螯合化合物包含硫代乙醛或半硫代乙醛硫保护基团，这些保护基团在酸性 pH 值下进行的放射性标记反应中被置换，从而在所述硫原子和所述放射性核素之间形成键。由此产生的金属放射性核素螯合物具有诊断和治疗医学用途。
• EP0813425A4
  申请人：——

  公开号：EP0813425A4

  公开（公告）日：1998-09-09