5-phenyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole | 1342638-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-phenyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole
• 英文别名: 5-Phenyl-1-[4-(trifluoromethyl)phenyl]pyrazole
• CAS: 1342638-78-1
• 化学式: C₁₆H₁₁F₃N₂
• 分子量: 288.272
• InChiKey: KFKCHPQVJXGVCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (Z)-1-(3-phenylprop-2-yn-1-ylidene)-2-(4-(trifluoromethyl)-phenyl)hydrazine 在 copper(l) iodide 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以83%的产率得到5-phenyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole
  参考文献：
  名称：

  Synthesis of Pyrazoles via CuI-Mediated Electrophilic Cyclizations of α,β-Alkynic Hydrazones

  摘要：

  Synthesis of pyrazoles via electrophilic cyclization of alpha,beta-alkynic hydrazones by copper(I) iodide is described. When treated with copper(I) iodide in the presence of triethylamine in refluxing acetonitrile, alpha,beta-alkynic hydrazones, prepared readily from hydrazines and propargyl aldehydes and ketones, undergo electrophilic cyclization to afford pyrazole derivatives in good to excellent yields. The reaction appears to be general for a variety of alpha,beta-alkynic hydrazones and tolerates the presence of aliphatic, aromatic, and ferrocenyl moieties with electron-withdrawing and electron-donating substituents.

  DOI：

  10.1021/jo201685p

文献信息

• Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: synthesis of <i>N</i>-arylpyrazoles
  作者：Jidan Liu、Erjie Xu、Jinyuan Jiang、Zeng Huang、Liyao Zheng、Zhao-Qing Liu

  DOI：10.1039/c9cc09657d

  日期：——

  A general method for the synthesis of structurally diverse N-arylpyrazoles from readily available cyclopropanols and aryldiazonium salts is disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity.

  公开了一种由容易获得的环丙醇和芳基重氮盐合成结构多样的N-芳基吡唑的通用方法。该反应在室温下在数分钟内以宽的底物范围和优异的区域选择性进行。
• I₂-Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones and Hydrazines
  作者：Xinting Zhang、Jinfeng Kang、Pengfei Niu、Jie Wu、Wenquan Yu、Junbiao Chang

  DOI：10.1021/jo501844x

  日期：2014.11.7

  An I2-mediated metal-free oxidative C–N bond formation methodology has been established for the regioselective pyrazole synthesis. This practical and eco-friendly one-pot protocol requires no isolation of the less stable intermediates hydrazones and provides a facile access to a variety of di-, tri-, and tetrasubstituted (aryl, alkyl, and/or vinyl) pyrazoles from readily available α,β-unsaturated aldehydes/ketones

  I 2介导的无金属氧化C–N键形成方法已建立用于区域选择性吡唑合成。这种实用且环保的一锅操作方案无需分离不稳定程度较高的中间体s，并易于从容易获得的多种二，三和四取代（芳基，烷基和/或乙烯基）吡唑中分离α，β-不饱和醛/酮和肼盐。
• Synthesis of Pyrazoles via CuI-Mediated Electrophilic Cyclizations of α,β-Alkynic Hydrazones
  作者：Metin Zora、Arif Kivrak

  DOI：10.1021/jo201685p

  日期：2011.11.18

  Synthesis of pyrazoles via electrophilic cyclization of alpha,beta-alkynic hydrazones by copper(I) iodide is described. When treated with copper(I) iodide in the presence of triethylamine in refluxing acetonitrile, alpha,beta-alkynic hydrazones, prepared readily from hydrazines and propargyl aldehydes and ketones, undergo electrophilic cyclization to afford pyrazole derivatives in good to excellent yields. The reaction appears to be general for a variety of alpha,beta-alkynic hydrazones and tolerates the presence of aliphatic, aromatic, and ferrocenyl moieties with electron-withdrawing and electron-donating substituents.