1,5-bis(2,4-dichlorophenyl)-1H-1,2,4-triazole | 1142938-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,5-bis(2,4-dichlorophenyl)-1H-1,2,4-triazole
• 英文别名: 1,5-Bis(2,4-dichlorophenyl)-1h-1,2,4-triazole；1,5-bis(2,4-dichlorophenyl)-1,2,4-triazole
• CAS: 1142938-29-1
• 化学式: C₁₄H₇Cl₄N₃
• 分子量: 359.042
• InChiKey: SUTYCESQHRGEOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4-二氯苯肼盐酸盐 、 2,4-dichloro-N-[(dimethylamino)methylene]benzamide 在 溶剂黄146 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 5.0h， 以3%的产率得到1,5-bis(2,4-dichlorophenyl)-1H-1,2,4-triazole
  参考文献：
  名称：

  Novel derivatives of 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles and their pharmacological evaluation as CB1 cannabinoid ligands

  摘要：

  In a previous study, we have identified 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles to be a novel class of cannabinoid type-1 (CB1) receptor antagonists. However, the synthesis yields for the ligands were low. Here we present an alternative synthesis pathway with improved yields. In addition, we have synthezised new structural derivatives and studied their results in competitive radioligand binding assays for cannabinoid receptors.

  DOI：

  10.1007/s00706-008-0890-8

文献信息

• Novel derivatives of 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles and their pharmacological evaluation as CB1 cannabinoid ligands
  作者：Laura Hernandez-Folgado、Pilar Goya、Jordi Frigola、María Rosa Cuberes、Alberto Dordal、Jörg Holenz、Nadine Jagerovic

  DOI：10.1007/s00706-008-0890-8

  日期：2008.9

  In a previous study, we have identified 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles to be a novel class of cannabinoid type-1 (CB1) receptor antagonists. However, the synthesis yields for the ligands were low. Here we present an alternative synthesis pathway with improved yields. In addition, we have synthezised new structural derivatives and studied their results in competitive radioligand binding assays for cannabinoid receptors.