2-methyl-1-vinyl-1H-indole | 21476-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-methyl-1-vinyl-1H-indole
• 英文别名: 1-Vinyl-2-methylindole；2-methyl-N-vinylindole；1-ethenyl-2-methylindole
• CAS: 21476-60-8
• 化学式: C₁₁H₁₁N
• 分子量: 157.215
• InChiKey: CCRAQNXKHZFYJM-UHFFFAOYSA-N

物化性质

• 沸点：
  105 °C(Press: 2 Torr)
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-甲基吲哚 、 calcium carbide 在 caesium carbonate 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 12.0h， 以78%的产率得到2-methyl-1-vinyl-1H-indole
  参考文献：
  名称：

  使用碳化钙作为乙炔替代物对吲哚和苯酚进行乙烯基化的原子经济方法

  摘要：

  据报道，吲哚的有效 N-乙烯基化和酚的 O-乙烯基化得到 N-乙烯基吲哚和苯基乙烯基醚。在标准实验室设置中，在湿溶剂中用碳化钙处理吲哚或苯酚后，可以以令人满意的收率（65-92%）生产乙烯基化产品。该反应的主要特点包括使用碳化钙作为安全且廉价的缓慢释放乙炔源，在简单的反应条件下进行 N-和 O-乙烯基化，无需金属催化剂或卤化底物。

  DOI：

  10.1002/ejoc.201600666

文献信息

• An Atom-Economic Approach for Vinylation of Indoles and Phenols Using Calcium Carbide as Acetylene Surrogate
  作者：Eakkaphon Rattanangkool、Tirayut Vilaivan、Mongkol Sukwattanasinitt、Sumrit Wacharasindhu

  DOI：10.1002/ejoc.201600666

  日期：2016.9

  An efficient N-vinylation of indoles and O-vinylation of phenols to give N-vinyl indoles and phenyl vinyl ethers is reported. The vinylated products can be produced in satisfactory to excellent yields (65–92 %) upon treatment of indoles or phenols with calcium carbide in wet solvents in a standard laboratory setup. Key features of this reaction include the use of calcium carbide as a safe and inexpensive

  据报道，吲哚的有效 N-乙烯基化和酚的 O-乙烯基化得到 N-乙烯基吲哚和苯基乙烯基醚。在标准实验室设置中，在湿溶剂中用碳化钙处理吲哚或苯酚后，可以以令人满意的收率（65-92%）生产乙烯基化产品。该反应的主要特点包括使用碳化钙作为安全且廉价的缓慢释放乙炔源，在简单的反应条件下进行 N-和 O-乙烯基化，无需金属催化剂或卤化底物。
• Anti-fouling agent
  申请人：Nitto Kasei Co., Ltd.

  公开号：EP0091039A2

  公开（公告）日：1983-10-12

  An antifouling agent comprising as an antifouling component a substantially linear triorganotin-containing copolymer containing (a) at least one kind of N-coordinated triorganotin-containing recurring units of the formula (la) or (Ib) represented in the specification and (b) comonomer recurring units derived from at least one ethylenic vinyl compound as a comonomer. The antifouling agent is applied to a structure which is needed to be protected from fouling organisms to form a film of the copolymer on the structure.

  一种防污剂，其防污成分包括基本上线性的含三聚有机锡共聚物，该共聚物含有(a)至少一种如说明书中所示的式(la)或(Ib)的N-配位三聚有机锡循环单元和(b)作为共聚单体的至少一种乙烯基乙烯基化合物衍生的共聚单体循环单元。 将防污剂涂在需要防止污损生物的结构上，在该结构上形成一层共聚物薄膜。
• RESIN COMPOSITION FOR OPTICAL MOLDING
  申请人：Kuraray Noritake Dental Inc.

  公开号：EP3900693A1

  公开（公告）日：2021-10-27

  The present invention provides a resin composition for optical shaping that emits a weaker odor, enables easy fabrication of an object by virtue of its low viscosity, and can be made into a fabricated product having desirable toughness and water resistance when used for stereolithographic fabrication (particularly by vat stereolithography) and that is particularly suited for dental occlusal splints, mouth guards, and denture base materials. The present invention relates to a resin composition for optical shaping comprising: an α,β-unsaturated double bond group-containing compound (A) having a ring structure (a) containing a nitrogen atom; a (meth)acrylic acid ester compound (B) having a boiling point of 280°C or more at normal pressure, having a carbocyclic group, and having no nitrogen-containing heterocyclic group; a photopolymerization initiator (C); and optionally, a polyfunctional polymerizable monomer (E) having a molecular weight of 500 or less and not comprised in the α,β-unsaturated double bond group-containing compound (A) and the (meth)acrylic acid ester compound (B), wherein the content of the polyfunctional polymerizable monomer (E) having a molecular weight of 500 or less is 20 mass% or less relative to the total amount of polymerizable compounds comprised in the resin composition for optical shaping.

  本发明提供了一种用于光学整形的树脂组合物，该组合物散发的气味较弱，因其粘度低而易于制造物体，在用于立体光刻制造（特别是大桶立体光刻）时，可制成具有理想韧性和耐水性的制成品，特别适用于牙科咬合夹板、护齿板和义齿基底材料。本发明涉及一种用于光学塑形的树脂组合物，包括具有含氮原子的环结构 (a) 的含 α、β-不饱和双键基团的化合物 (A)；(甲基) 丙烯酸酯化合物 (B)，在常压下的沸点为 280°C 或更高，具有碳环基团，且不含含氮杂环基团；光聚合引发剂 (C)；以及可选的分子量为 500 或以下且不包含在含α，β-不饱和双键基团的化合物（A）和（甲基）丙烯酸酯化合物（B）中的多功能可聚合单体（E），其中分子量为 500 或以下的多功能可聚合单体（E）的含量占光学成型用树脂组合物中可聚合化合物总量的 20% 或以下。
• Reppe et al., Justus Liebigs Annalen der Chemie, 1956, vol. 601, p. 81,104
  作者：Reppe et al.

  DOI：——

  日期：——
• RESIN COMPOSITION FOR OPTICAL SHAPING
  申请人：KURARAY NORITAKE DENTAL INC.

  公开号：US20220041777A1

  公开（公告）日：2022-02-10

  A resin composition for optical shaping comprising: an α,β-unsaturated double bond group-containing compound (A) having a ring structure (a) containing a nitrogen atom; a (meth)acrylic acid ester compound (B) having a boiling point of 280° C. or more at normal pressure, having a carbocyclic group, and having no nitrogen-containing heterocyclic group; a photopolymerization initiator (C); and optionally, a polyfunctional polymerizable monomer (E) having a molecular weight of 500 or less and not comprised in the α,β-unsaturated double bond group-containing compound (A) and the (meth)acrylic acid ester compound (B), wherein the content of the polyfunctional polymerizable monomer (E) having a molecular weight of 500 or less is 20 mass % or less relative to the total amount of polymerizable compounds comprised in the resin composition for optical shaping.