cyclopentadecanecarbaldehyde | 344443-21-6

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: cyclopentadecanecarbaldehyde
• CAS: 344443-21-6
• 化学式: C₁₆H₃₀O
• 分子量: 238.414
• InChiKey: QMBITTWQCLWJDP-UHFFFAOYSA-N

物化性质

• 沸点：
  108-112 °C(Press: 0.05 Torr)
• 密度：
  0.9238 g/cm3(Temp: 21.7 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cyclopentadecanecarbaldehyde 在 乙醇 、 镍 作用下， 生成 cyclopentadecylmethanol
  参考文献：
  名称：

  贡献XXX的组合。La-Héxadécane-1,16-Dial凝汽器和De-L'H'Cadécane-1,18-Dial凝汽器

  摘要：

  DOI：

  10.1002/hlca.19370200180
• 作为产物：
  描述：

  cyclopentadecylmethanol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 cyclopentadecanecarbaldehyde
  参考文献：
  名称：

  [EN] ANTI-METATSTATIC AGENTS PREDICATED UPON POLYAMINE-MACROCYCLIC CONJUGATES
  [FR] AGENTS ANTIMÉTASTASIQUES À BASE DE CONJUGUÉS MACROCYCLIQUES DE POLYAMINE

  摘要：

  本文披露了一种新型的莫托波拉明化合物，其作为低毒性且具有高抗迁移活性的抗转移剂。这种无毒的抗转移剂可以单独或与已知和/或新疗法联合给予患有潜在或实际转移性癌症（如胰腺癌）的患者，以帮助阻止肿瘤的生长和扩散。

  公开号：

  WO2013148219A1

文献信息

• [EN] ANTI-METATSTATIC AGENTS PREDICATED UPON POLYAMINE-MACROCYCLIC CONJUGATES<br/>[FR] AGENTS ANTIMÉTASTASIQUES À BASE DE CONJUGUÉS MACROCYCLIQUES DE POLYAMINE
  申请人：UNIV CENTRAL FLORIDA RES FOUND

  公开号：WO2013148219A1

  公开（公告）日：2013-10-03

  Disclosed herein are novel motuporamine compounds that act as anti-metastatic agents with low toxicity and high anti-migration activity. The non-toxic, anti-metastatic agents may be given to patients with potential or actual metastatic cancers, such as pancreatic cancers, alone in combination with known and/or new therapies to help block the growth and spread of tumor(s)..

  本文披露了一种新型的莫托波拉明化合物，其作为低毒性且具有高抗迁移活性的抗转移剂。这种无毒的抗转移剂可以单独或与已知和/或新疗法联合给予患有潜在或实际转移性癌症（如胰腺癌）的患者，以帮助阻止肿瘤的生长和扩散。
• DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS
  申请人：Matsuyama Hironori

  公开号：US20100004438A1

  公开（公告）日：2010-01-07

  An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X 1 represents a nitrogen atom or a group —CH═, R 1 represents a group -Z-R 6 , in which Z represents a group —CO—, a group —CH(OH)— or the like, R 6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R 2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R 3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R 4 represents an imidazolyl lower alkyl group or the like.

  本发明的一个目的是提供一种在抗肿瘤活性方面大大改进且安全性优异的药物。根据本发明，提供了一种包含以下一般式（1）所表示的化合物或其盐作为活性成分的药物：[式1]其中X1代表氮原子或基团—CH═，R1代表一个基团-Z-R6，其中Z代表基团—CO—，基团—CH(OH)—或类似的基团，R6代表一个含有1至4个氮原子、氧原子或硫原子的5至15个成员的单环、双环或三环饱和或不饱和杂环基团，R2代表氢原子或卤原子，Y代表基团—O—，基团—CO—，基团—CH(OH)—或低碳烷基基团，A代表[式2]其中R3代表氢原子、低碳氧基基团或类似基团，p代表1或2，R4代表咪唑基低碳基团或类似基团。
• Regio‐ and Diastereoselective [3+2] Annulation of Aliphatic Aldimines with Alkenes by Scandium‐Catalyzed β‐C(sp ³ )−H Activation
  作者：Xuefeng Cong、Qingde Zhuo、Na Hao、Zhenbo Mo、Gu Zhan、Masayoshi Nishiura、Zhaomin Hou

  DOI：10.1002/anie.202115996

  日期：2022.2.7

  Half-sandwich scandium catalysts serve as a unique platform for the regio- and diastereoselective [3+2] annulation of aliphatic aldimines with alkenes via β-C(sp3)−H activation, affording a new family of multi-substituted aminocyclopentane derivatives from easily accessible aldimines and alkenes with broad substrate scope, high regio-, diastereoselectivity and 100 % atom-efficiency.

  半夹心钪催化剂作为一个独特的平台，通过 β-C(sp 3 )-H 活化，使脂肪族醛亚胺与烯烃发生区域选择性和非对映选择性 [3+2] 环化反应，从而提供了一个新的多取代氨基环戊烷衍生物家族易于获得的醛亚胺和烯烃，具有广泛的底物范围、高区域选择性、非对映选择性和 100% 原子效率。
• Aromatic Compounds
  申请人：Fukushima Tae

  公开号：US20070270422A1

  公开（公告）日：2007-11-22

  The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X 1 represents a nitrogen atom or a group —CH═; R 1 represents a group -Z-R 6 , wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R 6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R 2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R 3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R 4 represents an imidazolyl lower alkyl group or the like.

  本发明提供了一种新型化合物，具有抑制胶原生成的优异效果，并且具有较少的副作用，在安全性方面表现出色。本发明的化合物由以下通式（1）表示：[其中X1代表氮原子或基团—CH═；R1代表基团-Z-R6，其中Z代表基团—CO—、基团—CH(OH)—或类似基团，而R6代表具有1到4个氮原子、氧原子或硫原子的5-到15元的单环、双环或三环、饱和或不饱和杂环基团；R2代表氢原子、卤素原子或低碳链基团；Y代表基团—O—、基团—CO—、基团—CH(OH)—、低碳链基团或类似基团；A代表基团或类似基团，其中R3代表氢原子、低碳醚基团或类似基团，p代表1或2，而R4代表咪唑基低碳基团或类似基团。
• HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：Sumida Takumi

  公开号：US20100261720A1

  公开（公告）日：2010-10-14

  The present invention provides a heterocyclic compound represented by General Formula (1): wherein R 1 is a group R 5 —Z 1 —, etc., Z 1 is a lower alkylene group, etc., and R 5 is a group represented by General Formula; wherein R 13 is a hydrogen atom, etc., m is an integer from 1 to 5; R 2 is a hydrogen atom: Y is CH or N: A 1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R 3 is a hydrogen atom, etc.: R 4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R 3 and R 4 , together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

  本发明提供一种由通式(1)表示的杂环化合物：其中R1为R5-Z1-等基团，Z1为低碳烷基等，而R5则为通式所表示的基团；其中R13为氢原子等，m为1到5的整数；R2为氢原子；Y为CH或N；A1为选自吲哚二基基团等的杂环环；其中该杂环环可以具有至少一个取代基；T为-CO-等基团；R3为氢原子等；R4为低碳基基团，可以选择性地被一个或多个羟基取代等；R3和R4与它们所结合的氮原子一起可以结合成一个5-到10-成员的饱和杂环环，其中该杂环环可以具有至少一个取代基。本发明的杂环化合物具有抑制胶原蛋白产生和/或治疗肿瘤的优异效果。