2-[(4-tert-Butylcyclohexyl)oxy]ethan-1-ol | 116549-08-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(4-tert-Butylcyclohexyl)oxy]ethan-1-ol
• 英文别名: 2-(4-tert-butylcyclohexyl)oxyethanol
• CAS: 116549-08-7
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: AUDDQSZTLCWZDZ-UHFFFAOYSA-N

物化性质

• 沸点：
  278.7±8.0 °C(Predicted)
• 密度：
  0.93±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(4-tert-Butylcyclohexyl)oxy]ethan-1-ol 在 poly[4-(diacetoxyiodo)styrene] 、 碘 作用下， 以 乙腈 为溶剂， 反应 1.5h， 以71%的产率得到8-叔-丁基-1,4-二氧杂螺[4.5]癸烷
  参考文献：
  名称：

  I2 介导的光化学制备 2-取代的 1,3-二氧戊环和四氢呋喃与聚合物负载的高价碘试剂，PSDIB

  摘要：

  各种 2-取代的 1,3-二氧戊环、1,3-二氧六环和四氢呋喃在碘的存在下在辐照条件下从相应的醇与 PSDIB 中选择性地以良好到中等的产率获得。此外，PSDIB 被重复用于相同的反应，以保持环状产物的良好收率。

  DOI：

  10.1055/s-2005-864802

文献信息

• FURUTA, KYOJI;NAGATA, TAKUSHI;YAMAMOTO, HISASHI, TETRAHEDRON LETT., 29,(1988) N 18, 2215-2218
  作者：FURUTA, KYOJI、NAGATA, TAKUSHI、YAMAMOTO, HISASHI

  DOI：——

  日期：——
• NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS
  申请人：Beusker Patrick Henry

  公开号：US20130224227A1

  公开（公告）日：2013-08-29

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers
  申请人：SYNTARGA BV

  公开号：US20170274090A1

  公开（公告）日：2017-09-28

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• US9629924B2
  申请人：——

  公开号：US9629924B2

  公开（公告）日：2017-04-25
• I₂-Mediated Photochemical Preparation of 2-Substituted 1,3-Dioxolanes and Tetrahydrofurans from Alcohols with Polymer-Supported Hypervalent Iodine Reagent, PSDIB
  作者：Hideo Togo、Tomomasa Teduka

  DOI：10.1055/s-2005-864802

  日期：——

  Various 2-substituted 1,3-dioxolanes, 1,3-dioxanes, and tetrahydrofurans were obtained selectively in good to moderate yields from the corresponding alcohols with PSDIB in the presence of iodine under irradiation conditions. Moreover, PSDIB was repeatedly used for the same reactions keeping good yield of the cyclic product.

  各种 2-取代的 1,3-二氧戊环、1,3-二氧六环和四氢呋喃在碘的存在下在辐照条件下从相应的醇与 PSDIB 中选择性地以良好到中等的产率获得。此外，PSDIB 被重复用于相同的反应，以保持环状产物的良好收率。