1-(2-methoxyphenyl)but-3-en-1-ol | 7477-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2-methoxyphenyl)but-3-en-1-ol
• 英文别名: 1-(2-Methoxyphenyl)butan-1-ol
• CAS: 7477-03-4
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: HQFDIBDPUWTEJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-methoxyphenyl)but-3-en-1-ol 、 potassium hydrogensulfate 生成 1-((E)-But-1-enyl)-2-methoxy-benzene
  参考文献：
  名称：

  DURRANI A. A.; TYMAN J. H. P., J. CHEM. SOC. PERKIN TRANS., PART 1, 1979, NO 8, 2079-2087

  摘要：

  DOI：
• 作为产物：
  描述：

  酚菌酮 在 sodium tetrahydroborate 、 sodium hydride 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-(2-methoxyphenyl)but-3-en-1-ol
  参考文献：
  名称：

  Strehlke; Kessler, European Journal of Medicinal Chemistry, 1979, vol. 14, # 3, p. 231 - 237

  摘要：

  DOI：

文献信息

• A Green Approach for Allylations of Aldehydes and Ketones: Combining Allylborate, Mechanochemistry and Lanthanide Catalyst
  作者：Viviane de Souza、Cristiane Oliveira、Thiago de Souza、Paulo Menezes、Severino Alves、Ricardo Longo、Ivani Malvestiti

  DOI：10.3390/molecules21111539

  日期：——

  Secondary and tertiary alcohols synthesized via allylation of aldehydes and ketones are important compounds in bioactive natural products and industry, including pharmaceuticals. Development of a mechanochemical method using potassium allyltrifluoroborate salt and water, to successfully perform the allylation of aromatic and aliphatic carbonyl compounds is reported for the first time. By controlling

  通过醛和酮的烯丙基化合成的仲和叔醇是生物活性天然产物和工业（包括药物）中的重要化合物。首次报道了使用烯丙基三氟硼酸钾盐和水的机械化学方法的开发，以成功进行芳族和脂族羰基化合物的烯丙基化。通过控制研磨参数，该方法可以是选择性的，即对醛非常有效而对酮无效，但是通过使用镧系元素催化剂，与酮的反应实际上可以定量。催化反应也可以在温和的水性搅拌条件下进行。考虑到烯丙基化剂及其副产物，水性介质，能源效率和催化剂的使用，
• PROCESS FOR PREPARATING OPTICALLY ACTIVE COMPOUNDS
  申请人：Japan Science and Technology Corporation

  公开号：EP0916637A1

  公开（公告）日：1999-05-19

  The present invention relates to a novel, highly practical method for producing optically active compounds such as optically active alcohol and optically active amine useful for various utilities such as synthetic intermediates of drugs, liquid crystal materials, and optical resolution agents, comprising hydrogen transfer-type asymmetric reduction in the presence of a transition metal catalyst and an optically active nitrogen-containing compound or a transition metal catalyst with an optically active nitrogen-containing compound as the asymmetric ligand, and a hydrogen-donating organic or inorganic compound. In accordance with the present invention, characteristically, an optically active secondary alcohol can be recovered through the hydrogen transfer-type oxidation from racemic secondary alcohol or meso-type diol.

  本发明涉及一种生产光学活性化合物（如光学活性醇和光学活性胺）的新型、高度实用的方法，该方法可用于药物合成中间体、液晶材料和光学分辨剂等多种用途，包括在过渡金属催化剂和光学活性含氮化合物或过渡金属催化剂与光学活性含氮化合物作为不对称配体以及供氢有机或无机化合物存在下进行氢转移型不对称还原。 根据本发明，外消旋仲醇或中型二元醇通过氢转移型氧化可回收光学活性仲醇。
• METHOD FOR FORMING CONDUCTIVE FILM AND SINTERING PROMOTER
  申请人：Ishihara Chemical Co., Ltd.

  公开号：EP2871645A1

  公开（公告）日：2015-05-13

  In a conductive film forming method using photo sintering, a conductive film having low electric resistance is easily formed. Disclosed is a conductive film forming method in which a conductive film is formed using a photo sintering, which includes the steps of: forming a liquid film 2 made of a copper particulate dispersion on a substrate 1, drying the liquid film 2 to form a copper particulate layer 3, subjecting the copper particulate layer 3 to photo sintering to form a conductive film 4, attaching a sintering promoter 5 to the conductive film 4, and further subjecting the conductive film 4 having the sintering promoter 5 attached to photo sintering. The sintering promoter 5 is a compound which removes copper oxide from metallic copper. Thereby, the sintering promoter 5 removes a surface oxide film of copper particulates 21 in the conductive film 4.

  在使用光烧结的导电膜形成方法中，很容易形成具有低电阻的导电膜。 本发明公开了一种使用光烧结形成导电膜的导电膜形成方法，该方法包括以下步骤：在基板 1 上形成由铜微粒分散体制成的液膜 2，干燥液膜 2 以形成铜微粒层 3，将铜微粒层 3 进行光烧结以形成导电膜 4，在导电膜 4 上附着烧结促进剂 5，以及进一步将附有烧结促进剂 5 的导电膜 4 进行光烧结。烧结促进剂 5 是一种能从金属铜中去除氧化铜的化合物。因此，烧结促进剂 5 可去除导电膜 4 中铜微粒 21 的表面氧化膜。
• ADHESIVE COMPOSITION AND LAMINATE
  申请人：TOYO INK SC HOLDINGS CO., LTD.

  公开号：EP3239261A1

  公开（公告）日：2017-11-01

  Provided is an adhesive which, in a metal foil-containing laminated composite film used in a high temperature sterilization treatment, is resistant to the effects of moisture in the air during curing, has good workability when used as a solvent-free adhesive, and exhibits excellent adhesive strength and acid resistance. Provided is a method for producing an adhesive composition, the method including: a step of obtaining an alcohol-added isocyanate (E) by reacting a trifunctional or higher isocyanate compound (C2) and a monofunctional alcohol compound (D) at an equivalence ratio of isocyanate groups in the trifunctional or higher isocyanate compound (C2) : monofunctional alcohol (D) = 100 mol% : 25 to 65 mol%, and a step of mixing a polyisocyanate (A) containing a trifunctional or higher polyisocyanate (C1) and the alcohol-added isocyanate (E), and an alcohol (B) having an acid value of 0.5 to 30 mgKOH/g, so that the equivalence ratio between isocyanate groups in the polyisocyanate (A) and hydroxyl groups in the alcohol (B) (isocyanate groups/hydroxyl groups) is within a range from 0.7 to 2.5.

  本发明提供了一种粘合剂，在高温灭菌处理中使用的含金属箔的层压复合膜中，该粘合剂可抵抗固化过程中空气中水分的影响，作为无溶剂粘合剂使用时具有良好的可操作性，并表现出优异的粘合强度和耐酸性。本发明提供了一种生产粘合剂组合物的方法，该方法包括：第一步，通过使三官能团或更高官能团的异氰酸酯化合物（C2）和单官能团醇化合物（D）以三官能团或更高官能团异氰酸酯化合物（C2）中异氰酸酯基团的等效比进行反应，得到添加醇的异氰酸酯（E）：单官能醇 (D) = 100 mol% : 25 至 65 mol%，以及将含有三官能或更高异氰酸酯 (C1) 和醇加异氰酸酯 (E) 的多异氰酸酯 (A) 与酸值为 0.5 至 30 mgKOH/g 的醇 (B)，使多异氰酸酯 (A) 中的异氰酸酯基团与醇 (B) 中的羟基基团之间的等效比（异氰酸酯基团/羟基基团）在 0.7 至 2.5 的范围内。
• PHARMACEUTICAL COMPOSITION COMPRISING 5-DODECANOLIDE, PREPARATION THEREOF AND USE OF SAME
  申请人：Universitat de les Illes Balears

  公开号：EP3404054A1

  公开（公告）日：2018-11-21

  The invention relates to a pharmaceutical composition comprising 5-dodecanolide as an active ingredient. This active ingredient is isolated from pork lard using a specific treatment. The invention, therefore, also relates to a method for obtaining the composition of the invention, and to the use thereof for therapeutic purposes and, more specifically, for treating inflammatory conditions.

  本发明涉及一种以 5-十二内酯为活性成分的药物组合物。这种活性成分是通过特定的处理方法从猪油中分离出来的。因此，本发明还涉及一种获得本发明组合物的方法，以及将其用于治疗目的，更具体地说，用于治疗炎症。