N-hydroxy-4,5-diphenyl-2-oxazolehexanamide | 752256-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-hydroxy-4,5-diphenyl-2-oxazolehexanamide
• 英文别名: 2-Oxazolehexanamide, N-hydroxy-4,5-diphenyl-；6-(4,5-diphenyl-1,3-oxazol-2-yl)-N-hydroxyhexanamide
• CAS: 752256-46-5
• 化学式: C₂₁H₂₂N₂O₃
• 分子量: 350.417
• InChiKey: SUAALRVQFSNDKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HYDROXAMIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：SHIZUOKA COFFEIN CO., LTD.

  公开号：EP1787986A1

  公开（公告）日：2007-05-23

  A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1) : (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

  一种化合物抑制炎症细胞因子产生的IL-6和/或TNFα，并且在预防或治疗各种参与这些细胞因子的炎症性疾病和自身免疫性疾病方面非常有用。它是一个羟肟酸衍生物，由以下公式（1）表示：（1）（其中A和B分别表示苯等；n是1到8的整数；Y表示氧或硫）。这种化合物具有出色的白细胞介素-6和/或TNFα产生抑制活性，并且可用作各种炎症性疾病，自身免疫性疾病等的治疗剂。
• Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient
  申请人：Nakatogawa Kiyoshi

  公开号：US20070208065A1

  公开（公告）日：2007-09-06

  A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

  一种化合物，可以抑制炎症细胞因子产生的IL-6和/或TNFα，对于预防或治疗各种参与这些细胞因子的炎症性疾病和自身免疫性疾病非常有用。它是一个羟肟酸衍生物，由以下公式（1）表示：（其中A和B分别表示苯等；n为1至8的整数；Y表示氧或硫）。该化合物具有出色的白细胞介素-6和/或TNFα产生抑制活性，并可用作各种炎症性疾病、自身免疫性疾病等的治疗药物。
• US7521563B2
  申请人：——

  公开号：US7521563B2

  公开（公告）日：2009-04-21