1,5-Cyclopentadecanediol, 3-methyl- | 78430-42-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,5-Cyclopentadecanediol, 3-methyl-
• 英文别名: 3-methylcyclopentadecane-1,5-diol
• CAS: 78430-42-9
• 化学式: C₁₆H₃₂O₂
• 分子量: 256.42
• InChiKey: YNXMWLJDUHGJMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] SYNTHESIS OF 14-METHYL-16-OXABICYCLO[10.3.1]HEXADEC-12-ENE<br/>[FR] SYNTHÈSE DE 14-MÉTHYL-16-OXABICYCLO [10.3.1] HEXADÉC-12-ÈNE
  申请人：INT FLAVORS & FRAGRANCES INC

  公开号：WO2020150454A1

  公开（公告）日：2020-07-23

  Disclosed is a scalable process for preparation of 14-methyl-16-oxabicyclo[10.3.1]hexadec-12-ene (BCE), a key intermediate for manufacture of fragrance ingredient 3-methylcyclopentadecenone (MUSCENONE®) and analogs through reaction of 3-Methyl-1,5-cyclopentadecanedione (MCPD) and analogs with a metal or metalloid alkoxide in high yield and purity.

  本发明公开了一种可扩展的制备14-甲基-16-氧杂双环[10.3.1]十六烷-12-烯（BCE）的过程，该过程通过将3-甲基-1,5-环戊二酮（MCPD）和类似物与金属或类金属烷氧基反应，高产率高纯度制备香料成分3-甲基环戊十五烯酮（MUSCENONE®）和类似物的关键中间体。
• METHOD FOR PRODUCING CYCLIC DIKETONE COMPOUND
  申请人：Kao Corporation

  公开号：US20170362153A1

  公开（公告）日：2017-12-21

  Provided is a method for producing a compound represented by general formula (I) by oxidative cleavage of a compound of formula (II), which is a bicyclic tetrasubstituted olefin compound, using hydrogen peroxide. The method for producing a compound represented by general formula (I) includes a step of subjecting a compound represented by general formula (II) to oxidative cleavage using hydrogen peroxide in the presence of an acid catalyst or in the presence of a tungstic acid compound to obtain the compound represented by general formula (I): [In the formulae, formula -A 1 - (where the front bond denotes a bond that bonds with a carbon atom C 1 while the back bond denotes a bond that bonds with a carbon atom C 2 ) is an alkylene group having 2 to 6 carbon atoms that may have been substituted and that may further include an ether bond, an ester bond, a secondary amino group, a thioether group, or these, and formula -A 2 - (where the front bond denotes a bond that bonds with a carbon atom C 1 while the back bond denotes a bond that bonds with a carbon atom C 2 ) is an alkylene group having 4 to 10 carbon atoms that may have been substituted and that may further include an ether bond, an ester bond, a secondary amino group, a thioether group, or these.]

  提供了一种通过使用过氧化氢对式为(II)的双环四取代烯烃化合物进行氧化裂解来制备通式(I)化合物的方法。制备通式(I)化合物的方法包括以下步骤：将通式(II)化合物在酸催化剂或钨酸化合物存在下，使用过氧化氢进行氧化裂解，以获得通式(I)化合物。[在公式中，公式-A1-（其中前面的键表示与碳原子C1结合的键，而后面的键表示与碳原子C2结合的键）是具有2至6个碳原子的脂肪族基，可能已被取代，并且可能进一步包括醚键，酯键，次级氨基，硫醚基或这些基团，而公式-A2-（其中前面的键表示与碳原子C1结合的键，而后面的键表示与碳原子C2结合的键）是具有4至10个碳原子的脂肪族基，可能已被取代，并且可能进一步包括醚键，酯键，次级氨基，硫醚基或这些基团。]
• METHOD FOR PRODUCING CYCLIC ENOL ETHER COMPOUND
  申请人：Kao Corporation

  公开号：US20220119404A1

  公开（公告）日：2022-04-21

  Provided is a one-step method for producing an enol ether using a diketone of a macrocyclic compound as a starting material. A method for producing a compound represented by general formula (I) includes reacting a compound represented by general formula (II) in the presence of a metal catalyst containing at least one metal element selected from the group consisting of magnesium, aluminum, zirconium, titanium, and samarium, and an alcohol containing at least one selected from the group consisting of a primary alcohol and a secondary alcohol to obtain the compound represented by general formula (I).

  提供了一种使用大环化合物的二酮作为起始物质生产烯醚的一步法。一种生产通式（I）所表示的化合物的方法包括在含有至少一种从镁、铝、锆、钛和钐组成的金属催化剂和至少一种从一级醇和二级醇组成的醇的存在下，使通式（II）所表示的化合物反应，以获得通式（I）所表示的化合物。
• Method for the preparation of compounds having a 16-oxabicyclo[10.3.1]pentadecene scaffold and the subsequent products thereof
  申请人：BASF SE

  公开号：US20180346478A1

  公开（公告）日：2018-12-06

  The present invention relates to a method for preparing compounds having a 16-oxabicyclo[10.3.1]pentadecene skeleton, specifically 14-methyl-16-oxabicyclo[10.3.1]pentadecenes, and conversion products thereof.

  本发明涉及一种制备具有16-氧杂双环[10.3.1]十五碳烯骨架的化合物的方法，特别是14-甲基-16-氧杂双环[10.3.1]十五碳烯及其转化产物。
• [EN] PREPARATION OF 14-METHYL-16-OXABICYCLO[10.3.1]PENTADECENES FROM 3-METHYL-1,5-CYCLOPENTADECANEDIONE<br/>[FR] PRÉPARATION DE 14-MÉTHYL-16-OXABICYCLO [10.3.1] PENTADEÈNES À PARTIR DE 3-MÉTHYL -1,5-CYCLOPENTADÉCANEDIONE
  申请人：BASF SE

  公开号：WO2018011386A1

  公开（公告）日：2018-01-18

  The present invention relates to a method for preparing 14-methyl-16-oxabicyclo- [10.3.1]pentadecenesin a two-step synthesis from 3-methyl-1,5-cyclopentadecane- dione as starting material.

  本发明涉及一种制备14-甲基-16-氧代双环[10.3.1]十五烯的方法，该方法采用3-甲基-1,5-环戊十五酮为起始物质进行两步合成。