2-Cyclopentadienylethanol | 99286-99-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Cyclopentadienylethanol
• 英文别名: 2-cyclopenta-2,4-dien-1-ylethanol
• CAS: 99286-99-4
• 化学式: C₇H₁₀O
• 分子量: 110.156
• InChiKey: STHSPBANQBKJGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Cyclopentadienylethanol 、 Zr(NEt2)4 以 not given 为溶剂， 以>99的产率得到
  参考文献：
  名称：

  Herrmann, Wolfgang A.; Morawietz, Marcus J. A.; Priermeier, Thomas, Angewandte Chemie, 1994, vol. 106, p. 2025 - 2028

  摘要：

  DOI：

文献信息

• [EN] METHOD AND MOLECULES<br/>[FR] MÉTHODE ET MOLÉCULES
  申请人：MEDIMMUNE LLC

  公开号：WO2018218093A1

  公开（公告）日：2018-11-29

  The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

  本发明提供了一种生物共轭方法和其中使用的化合物。该生物共轭方法包括将含有第一不饱和官能团的生物分子与包含第二不饱和官能团的荷载物质共轭的步骤，其中第一和第二不饱和官能团互补，使得通过 Diels-Alder 反应发生官能团之间的结合，形成一个环己烯环。
• Reaction of a naphthalene complex C10H8Yb(THF)2 with cyclopentadienyl-substituted alcohols and amines as a convenient synthetic route to the half-sandwich complexes of divalent ytterbium
  作者：A. A. Trifonov、E. N. Kirillov、Yu. A. Kurskii、M. N. Bochkarev

  DOI：10.1007/bf02495495

  日期：2000.4

  The reactions of ytterbium naphthalene complex C10H8Yb(THF)2 with 2-cyclopentadienylethanol, 1-cyclopentadienylpropan-2-ol, 3-cyclopentadienyl-1-butoxypropan-2-ol, and cyclopentadienyldimethylsilyl-tert-butylamine were studied. The bivalent ytterbium complexes with chelate bifunctional cyclopentadienyl ligands [(η5−C5H5)CH2CH2(η1−O)]Yb(THF), [(η5−C5H5)CH2CH2(η1−O)]Yb(DME). [(η5−C5H5)CH2CH(Me)(η1−O)]Yb(THF)

  研究了镱萘配合物C10H8Yb(THF)2与2-环戊二烯基乙醇、1-环戊二烯基丙-2-醇、3-环戊二烯基-1-丁氧基丙-2-醇和环戊二烯基二甲基甲硅烷基-叔丁胺的反应。二价镱与螯合双功能环戊二烯基配体 [(η5−C5H5)CH2CH2(η1−O)]Yb(THF)、[(η5− )CH2CH2(η1−O)]Yb(DME) 络合物。[(η5− )CH2CH(Me)(η1−O)]Yb(THF)、[(η5− )CH2CH(CH2OC4H9)(η1−O)]Yb(THF) 和 [(η5− )SiMe2获得并表征了 (η1-N(Bu1))]Yb(THF)。
• METHOD AND MOLECULES
  申请人：Medimmune, LLC

  公开号：EP3630732A1

  公开（公告）日：2020-04-08
• Method And Molecules
  申请人：MedImmune, LLC

  公开号：US20200206359A1

  公开（公告）日：2020-07-02

  The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.