3-(叔丁基氨基)丙酸盐酸盐 | 51482-99-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-(叔丁基氨基)丙酸盐酸盐
• 英文名称: β-tert-butylaminopropionic acid
• 英文别名: 2-Carboxyethyl-t.-butylamin；3-tert.-Butylamino-propionsaeure；t-butyl-β-alanine；3-(Tert-butylazaniumyl)propanoate
• CAS: 51482-99-6
• 化学式: C₇H₁₅NO₂
• mdl: MFCD06208064
• 分子量: 145.202
• InChiKey: GDMFYPNVLLFABQ-UHFFFAOYSA-N

物化性质

• 沸点：
  237.4±23.0 °C(Predicted)
• 密度：
  0.983±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  3-(叔丁基氨基)丙酸盐酸盐 在 磷酸 、 水 、 三氯化磷 作用下， 生成 1-hydroxy-3-tert-butylaminopropylidenephosphonic acid
  参考文献：
  名称：

  NewN-substituted 1-hydroxy-3-aminopropylidenediphosphonic acids

  摘要：

  N-Substituted 1-hydroxy-3-aminopropylidenediphosphonic acids were synthesized. Their acid-base and complexation properties toward a wide series of metal cations in water were investigated.

  DOI：

  10.1007/bf02495695
• 作为产物：
  描述：

  叔丁胺 、 丙烯酸甲酯（MA） 反应 48.0h， 以79%的产率得到3-(叔丁基氨基)丙酸盐酸盐
  参考文献：
  名称：

  NewN-substituted 1-hydroxy-3-aminopropylidenediphosphonic acids

  摘要：

  N-Substituted 1-hydroxy-3-aminopropylidenediphosphonic acids were synthesized. Their acid-base and complexation properties toward a wide series of metal cations in water were investigated.

  DOI：

  10.1007/bf02495695

文献信息

• CHEMICAL UNCOUPLERS OF RESPIRATION AND METHODS OF USE THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20200317613A1

  公开（公告）日：2020-10-08

  Uncoupling of respiration is a well-recognized process that increases respiration and heat production in cells. Provided herein are chemical uncouplers of respiration that are compounds of Formula (I). Also provided are methods for preventing or treating metabolic disorders and modulating metabolic processes using compound of Formula (I).

  解耦呼吸是一个众所周知的过程，可以增加细胞的呼吸和产热。本文提供了化学解耦剂，这些解耦剂是化合物(I)的化合物。还提供了使用化合物(I)预防或治疗代谢性疾病和调节代谢过程的方法。
• Coupling agents and sterically hindered disulfide linked conjugates
  申请人：Cetus Oncology

  公开号：US05241078A1

  公开（公告）日：1993-08-31

  This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second group reactive toward nucleophiles such as 1.degree. and 2.degree. amines or reactive thiols that are present on biological and organic materials. The coupling agents are useful for making conjugates containing a sterically hindered linkage.

  该发明揭示了用于制备各种分子共轭物的异噻唑双官能团偶联剂。该剂含有一个立体障碍硫醇，通过一个间隔臂与第二个反应于生物和有机材料上存在的亲核物如1度和2度胺或反应性硫醇的基团连接。这些偶联剂可用于制备含有立体障碍连接的共轭物。
• Arylindenopyridines and related therapeutic and prophylactic methods
  申请人：——

  公开号：US20040082578A1

  公开（公告）日：2004-04-29

  This invention provides novel arylindenopyridines of the formula: 1 and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

  本发明提供了新型的芳基茚莽啶化合物的公式1及其制成的药物组合物，用于治疗通过拮抗腺苷A2a受体或在适当的细胞中减少PDE活性而改善的疾病。本发明还提供了使用该药物组合物的治疗和预防方法。
• Absorbent composition containing molecules with a hindered amine and a metal sulfonate, phosphonate or carboxylate structure for acid gas scrubbing process
  申请人：Siskin Michael

  公开号：US20090308248A1

  公开（公告）日：2009-12-17

  An acid gas absorbent comprising a metal sulfonate, phosphonate or carboxylate of a hindered amine and a process for the selective removal Of H2S as well as other acidic components such as carbon disulfide, carbonyl sulfide and oxygen and sulfur derivatives of C1 to C4 hydrocarbons from mixtures containing such acidic components and CO2 using said absorbent.

  一种酸性气体吸收剂，包括一种受阻胺的金属磺酸盐、膦酸盐或羧酸盐，以及一种用该吸收剂选择性去除H2S以及其他酸性成分（如二硫化碳、羰基硫和C1至C4烃类的氧和硫衍生物）和二氧化碳的混合物的方法。
• OXAZOLE PYRIDINE DERIVATIVES USEFUL AS S1P1 RECEPTOR AGONISTS
  申请人：Quattropani Anna

  公开号：US20110306636A1

  公开（公告）日：2011-12-15

  The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.

  本发明提供了式（I）的噁唑吡啶衍生物，其用作药物治疗多发性硬化症和其他疾病。