(+)-20R-dihydrocleavamine | 379228-18-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (+)-20R-dihydrocleavamine
• 英文别名: (+)-20R-15,20-dihydro-cleavamine；(15S,17R)-17-ethyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraene
• CAS: 379228-18-9
• 化学式: C₁₉H₂₆N₂
• 分子量: 282.429
• InChiKey: KFWYCGGJKBFGRT-CABCVRRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (15R,17R)-17-ethyl-11-aza-1-azoniapentacyclo[13.3.1.01,13.04,12.05,10]nonadeca-4(12),5,7,9-tetraene;methanesulfonate 在 氨 、 sodium 作用下， 以 四氢呋喃 、 叔丁醇 为溶剂， 生成 (+)-20R-dihydrocleavamine
  参考文献：
  名称：

  A stereoselective synthesis of naturally occurring (+)-20 R -dihydrocleavamine by photo-[2+2]-cycloreversion

  摘要：

  A stereoselective synthesis of (+)-20R-dihydrocleavamine, an alkaloid from Pandaca eusepala and Tabernamontana eglandulose, has been developed using an enantiopure tricyclic ketone accessible from a meso precursor by employing a photo-[2+2]-cycloreversion reaction as the key step. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01538-6

文献信息

• A stereoselective synthesis of naturally occurring (+)-20 R -dihydrocleavamine by photo-[2+2]-cycloreversion
  作者：Regina Mikie Kanada、Kunio Ogasawara

  DOI：10.1016/s0040-4039(01)01538-6

  日期：2001.10

  A stereoselective synthesis of (+)-20R-dihydrocleavamine, an alkaloid from Pandaca eusepala and Tabernamontana eglandulose, has been developed using an enantiopure tricyclic ketone accessible from a meso precursor by employing a photo-[2+2]-cycloreversion reaction as the key step. (C) 2001 Elsevier Science Ltd. All rights reserved.