(S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[(R)-4-benzyloxy-1-((S)-2-hydroxy-1-methyl-ethyl)-butyl] ester | 452085-16-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[(R)-4-benzyloxy-1-((S)-2-hydroxy-1-methyl-ethyl)-butyl] ester
• 英文别名: 1-O-benzyl 2-O-[(2S,3R)-1-hydroxy-2-methyl-6-phenylmethoxyhexan-3-yl] (2S)-pyrrolidine-1,2-dicarboxylate
• CAS: 452085-16-4
• 化学式: C₂₇H₃₅NO₆
• 分子量: 469.578
• InChiKey: YPQLYVJSCWBBAV-GVXSCFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  85.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[(R)-4-benzyloxy-1-((S)-2-hydroxy-1-methyl-ethyl)-butyl] ester 在 lithium hydroxide 、 水 作用下， 以 甲醇 为溶剂， 生成 (2S,3R)-6-Benzyloxy-2-methyl-hexane-1,3-diol
  参考文献：
  名称：

  A stereocontrolled synthetic route to the C1C18 subunit of pamamycin-607

  摘要：

  The C1 C18 subunit 2 of the 16-membered macrodiolide pamamycin-607 has been synthesized stereo selectively using the Ag2CO3-mediated intramolecular iodoetherification for the two cis-2,5-disubstituted tetrahydrofurans, crotylation and cuprate epoxide opening for the hydroxyl and methyl substituents. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00655-x
• 作为产物：
  描述：

  (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[1-(3-benzyloxy-propyl)-3,4-dihydroxy-2-methyl-butyl] ester 在 sodium tetrahydroborate 、 sodium periodate 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[(R)-4-benzyloxy-1-((S)-2-hydroxy-1-methyl-ethyl)-butyl] ester
  参考文献：
  名称：

  A stereocontrolled synthetic route to the C1C18 subunit of pamamycin-607

  摘要：

  The C1 C18 subunit 2 of the 16-membered macrodiolide pamamycin-607 has been synthesized stereo selectively using the Ag2CO3-mediated intramolecular iodoetherification for the two cis-2,5-disubstituted tetrahydrofurans, crotylation and cuprate epoxide opening for the hydroxyl and methyl substituents. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00655-x

文献信息

• A stereocontrolled synthetic route to the C1C18 subunit of pamamycin-607
  作者：Sung Ho Kang、Joon Won Jeong

  DOI：10.1016/s0040-4039(02)00655-x

  日期：2002.5

  The C1 C18 subunit 2 of the 16-membered macrodiolide pamamycin-607 has been synthesized stereo selectively using the Ag2CO3-mediated intramolecular iodoetherification for the two cis-2,5-disubstituted tetrahydrofurans, crotylation and cuprate epoxide opening for the hydroxyl and methyl substituents. (C) 2002 Elsevier Science Ltd. All rights reserved.