3-bromofascaplysin | 718596-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-bromofascaplysin
• 英文别名: 16-Bromo-3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14(19),15,17-nonaen-20-one
• CAS: 718596-89-5
• 化学式: C₁₈H₁₀BrN₂O
• 分子量: 350.194
• InChiKey: PTIZIDHSSRNUKQ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  草酸二甲酯 、 3-bromofascaplysin 反应 0.5h， 以23%的产率得到3-bromohomofascaplysin B-1
  参考文献：
  名称：

  One-step transformation of the marine alkaloid fascaplysin into homofascaplysins B and B-1. The first syntheses of 3-bromohomofascaplysin B and 3–bromohomofascaplysin B-1

  摘要：

  A method for one-step conversion of the marine alkaloid fascaplysin into homofascaplysins B and B-1 was elaborated. It was also used for the first syntheses of the marine alkaloids 3-bromohomofascaplysin B and 3-bromohomofascaplysin B-1. The best results were demonstrated under the action of microwave irradiation in presents of dihydroquinone as a reducing agent. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2018.02.070

文献信息

• One-step transformation of the marine alkaloid fascaplysin into homofascaplysins B and B-1. The first syntheses of 3-bromohomofascaplysin B and 3–bromohomofascaplysin B-1
  作者：Maxim E. Zhidkov、Maria A. Sidorova、Irina A. Lyakhova

  DOI：10.1016/j.tetlet.2018.02.070

  日期：2018.4

  A method for one-step conversion of the marine alkaloid fascaplysin into homofascaplysins B and B-1 was elaborated. It was also used for the first syntheses of the marine alkaloids 3-bromohomofascaplysin B and 3-bromohomofascaplysin B-1. The best results were demonstrated under the action of microwave irradiation in presents of dihydroquinone as a reducing agent. (C) 2018 Elsevier Ltd. All rights reserved.