[(3aR,3'aS,4R,6'S,7R,7'R,7aS,7'aR)-7'-[tert-butyl(dimethyl)silyl]oxy-6'-[(2S,3S,4S,5R,6R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[(2S,3R,4S,5S,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[(2S,3S,4S,5R,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-5-methoxy-6-methyloxan-2-yl]oxy-3-methoxy-6-(methoxymethyl)oxan-2-yl]oxyspiro[3a,6,7,7a-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4,2'-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran]-7-yl] 2,4-bis[[tert-butyl(dimethyl)silyl]oxy]-6-methylbenzoate | 256413-52-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(3aR,3'aS,4R,6'S,7R,7'R,7aS,7'aR)-7'-[tert-butyl(dimethyl)silyl]oxy-6'-[(2S,3S,4S,5R,6R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[(2S,3R,4S,5S,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[(2S,3S,4S,5R,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-5-methoxy-6-methyloxan-2-yl]oxy-3-methoxy-6-(methoxymethyl)oxan-2-yl]oxyspiro[3a,6,7,7a-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4,2'-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran]-7-yl] 2,4-bis[[tert-butyl(dimethyl)silyl]oxy]-6-methylbenzoate
• CAS: 256413-52-2
• 化学式: C₇₇H₁₄₄O₂₅Si₆
• 分子量: 1638.49
• InChiKey: JSPURFYIIFQPJE-MEZDDEHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.21
• 重原子数：
  108
• 可旋转键数：
  31
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  261
• 氢给体数：
  2
• 氢受体数：
  25

反应信息

• 作为反应物：
  描述：

  、 [(3aR,3'aS,4R,6'S,7R,7'R,7aS,7'aR)-7'-[tert-butyl(dimethyl)silyl]oxy-6'-[(2S,3S,4S,5R,6R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[(2S,3R,4S,5S,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[(2S,3S,4S,5R,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-5-methoxy-6-methyloxan-2-yl]oxy-3-methoxy-6-(methoxymethyl)oxan-2-yl]oxyspiro[3a,6,7,7a-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4,2'-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran]-7-yl] 2,4-bis[[tert-butyl(dimethyl)silyl]oxy]-6-methylbenzoate 在 tin(ll) chloride 作用下， 以 乙醚 为溶剂， 反应 6.0h， 以70%的产率得到
  参考文献：
  名称：

  Total Synthesis of Everninomicin 13,384-1—Part 3: Synthesis of the DE Fragment and Completion of the Total Synthesis

  摘要：

  DOI：

  10.1002/(sici)1521-3773(19991115)38:22<3345::aid-anie3345>3.0.co;2-9
• 作为产物：
  描述：

  在 甲醇 、 potassium carbonate 作用下， 反应 0.25h， 以85%的产率得到[(3aR,3'aS,4R,6'S,7R,7'R,7aS,7'aR)-7'-[tert-butyl(dimethyl)silyl]oxy-6'-[(2S,3S,4S,5R,6R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[(2S,3R,4S,5S,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[(2S,3S,4S,5R,6R)-3-[tert-butyl(dimethyl)silyl]oxy-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-5-methoxy-6-methyloxan-2-yl]oxy-3-methoxy-6-(methoxymethyl)oxan-2-yl]oxyspiro[3a,6,7,7a-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4,2'-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran]-7-yl] 2,4-bis[[tert-butyl(dimethyl)silyl]oxy]-6-methylbenzoate
  参考文献：
  名称：

  Total Synthesis of Everninomicin 13,384-1—Part 3: Synthesis of the DE Fragment and Completion of the Total Synthesis

  摘要：

  DOI：

  10.1002/(sici)1521-3773(19991115)38:22<3345::aid-anie3345>3.0.co;2-9