3-(苄氧基)-6-氟吡嗪 | 870646-05-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-(苄氧基)-6-氟吡嗪
• 英文名称: 3-Benzyloxy-6-fluoropyridazine
• 英文别名: 3-(Benzyloxy)-6-fluoropyridazine；3-fluoro-6-phenylmethoxypyridazine
• CAS: 870646-05-2
• 化学式: C₁₁H₉FN₂O
• 分子量: 204.204
• InChiKey: IWKTXEWKOWHYQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  吗啉 、 3-(苄氧基)-6-氟吡嗪 以80.5%的产率得到3-(4-morpholinyl)-6-benzyloxypyridazine
  参考文献：
  名称：

  Synthesis and Herbicidal Evaluation of 3-N-Substituted Amino-6-benzyloxypyridazine Derivatives

  摘要：

  A variety of 3‐N‐substituted amino‐6‐benzyloxypyridazine derivatives were designed and synthesized in satisfactory yields. Their structures were confirmed by IR, 1H‐NMR, and elemental analysis; compound 5j was further determined by X‐ray diffraction crystallography. Their herbicidal activities were evaluated through barnyard grass and rape cup tests in laboratory bioassays. Most of the title compounds 5 displayed moderate herbicidal activities against the dicotyledonous plant Brassica campestris L. The most active compounds in the laboratory were also evaluated in the greenhouse.

  DOI：

  10.1002/jhet.1831
• 作为产物：
  描述：

  3,6-二氟哒嗪 、 苯甲醇 在 sodium hydroxide 作用下， 以 乙腈 为溶剂， 生成 3-(苄氧基)-6-氟吡嗪
  参考文献：
  名称：

  Synthesis and Herbicidal Evaluation of 3-N-Substituted Amino-6-benzyloxypyridazine Derivatives

  摘要：

  A variety of 3‐N‐substituted amino‐6‐benzyloxypyridazine derivatives were designed and synthesized in satisfactory yields. Their structures were confirmed by IR, 1H‐NMR, and elemental analysis; compound 5j was further determined by X‐ray diffraction crystallography. Their herbicidal activities were evaluated through barnyard grass and rape cup tests in laboratory bioassays. Most of the title compounds 5 displayed moderate herbicidal activities against the dicotyledonous plant Brassica campestris L. The most active compounds in the laboratory were also evaluated in the greenhouse.

  DOI：

  10.1002/jhet.1831